Evidence map›Paper›PMID 33140121›Full record

ReviewCurrent genetics2021

Emerging roles of Wss1 in the survival of Candida albicans under genotoxic stresses.

Aimorn Homchan, Juthamas Sukted, Oranart Matangkasombut, Danaya Pakotiprapha

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Aimorn Homchan *Department of Biochemistry and Center for Excellence in Protein and Enzyme Technology, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand.ORCID https://orcid.org/0000-0002-1528-2915
Juthamas Sukted *Applied Biological Sciences Program, Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok, 10210, Thailand.
Oranart MatangkasombutLaboratory of Biotechnology, Chulabhorn Research Institute, Bangkok, 10210, Thailand. oranart.m@chula.ac.th.ORCID https://orcid.org/0000-0003-4029-6830
Danaya PakotipraphaDepartment of Biochemistry and Center for Excellence in Protein and Enzyme Technology, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand. danaya.pak@mahidol.ac.th.ORCID http://orcid.org/0000-0002-5017-8283
Mahidol University · THChulabhorn Graduate Institute · THChulalongkorn University · TH

Funding

Thailand Research Fund IRG598008Thailand Research Fund RSA6280087
6 · The paper itself

Abstract

This perspective aims to discuss the potential physiological roles and regulation mechanisms of the recently identified Candida albicans Wss1 protease important in DNA-protein crosslink (DPC) tolerance and repair. DPC is a bulky DNA lesion that blocks essential DNA transactions; thus, it poses a significant threat to genome integrity if left unrepaired. Discoveries of Wss1 in Saccharomyces cerevisiae and SPRTN in human as DPC proteases have demonstrated the importance of protease function in DPC repair. Our recent study revealed that Wss1 in C. albicans, an opportunistic pathogen that can cause life-threatening infection in immunocompromised individuals, also promotes DPC tolerance similarly to both S. cerevisiae Wss1 and human SPRTN. However, its molecular mechanism and regulation are still poorly understood. Here, we briefly discuss the recent insights into C. albicans Wss1 based on the information from S. cerevisiae, as well as outline the aspect of this protein that could make it a potential target for antifungal drug development.

Indexed as

ProteolysisCandida albicansDNADNA-Binding ProteinsDNA DamageDNA RepairHumansSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsDNADNA-Binding ProteinsSaccharomyces cerevisiae ProteinsWSS1 protein, S cerevisiaeCandida albicansDNA −protein crosslink repairSUMO processingWss1

Identifiers

PMID33140121
OpenAlexW3096217559

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.