ArticleQuantitative imaging in medicine and surgery2020
Dynamic contrast-enhanced near-infrared spectroscopy using indocyanine green on moderate and severe traumatic brain injury: a prospective observational study.
Article in Quantitative imaging in medicine and surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 17 citations in OpenAlex.
- Indocyanine green fluorescence-guided surgery in acute settings: state-of-the art.Frontiers in surgery · 2026Review
- Diffuse optical tomography system for acute traumatic brain injury in the intensive care unit: a prospective study on healthy volunteers.Journal of biomedical optics · 2025Article
- Phase-based structured interrogation frequency-domain near-infrared spectroscopy.Journal of the Optical Society of America. A, Optics, image science, and vision · 2024Article
- Review of Temperature Management in Traumatic Brain Injuries.Journal of clinical medicine · 2024Review
- Functional-structural large-scale brain networks are correlated with neurocognitive impairment in acute mild traumatic brain injury.Quantitative imaging in medicine and surgery · 2023Article
- Physiological oxygen measurementsFrontiers in bioengineering and biotechnology · 2023Article
- Comparison of cerebral metabolic rate of oxygen, blood flow, and bispectral index under general anesthesia.Neurophotonics · 2023Article
- Multi-modulated frequency domain high density diffuse optical tomography.Biomedical optics express · 2022Article
- Sterically Shielded Hydrophilic Analogs of Indocyanine Green.The Journal of organic chemistry · 2022Article
- Methods used for the measurement of blood-brain barrier integrity.Metabolic brain disease · 2021Review
- A novel wireless optical technique for quantitative evaluation of cerebral perfusion pressure in a fluid percussion animal model of traumatic brain injury.Quantitative imaging in medicine and surgery · 2021Article
- Quantitative evaluation of frequency domain measurements in high density diffuse optical tomography.Journal of biomedical optics · 2021Article
- Mismatch between Tissue Partial Oxygen Pressure and Near-Infrared Spectroscopy Neuromonitoring of Tissue Respiration in Acute Brain Trauma: The Rationale for Implementing a Multimodal Monitoring Strategy.International journal of molecular sciences · 2021Review
- Breakthrough in the assessment of cerebral perfusion and vascular permeability after brain trauma through the adoption of dynamic indocyanine green-enhanced near-infrared spectroscopy.Quantitative imaging in medicine and surgery · 2020Article
- Safety of Indocyanine Green Microdosing for Clinical Imaging of CSF Ventricular Dynamics and Extracranial Outflow.Journal of neuroimaging : official journal of the American Society of NeuroimagingReview
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe care given to moderate and severe traumatic brain injury (TBI) patients may be hampered by the inability to tailor their treatments according to their neurological status. Contrast-enhanced near-infrared spectroscopy (NIRS) with indocyanine green (ICG) could be a suitable neuromonitoring tool.
methodsMonitoring the effective attenuation coefficients (EAC), we compared the ICG kinetics between five TBI and five extracranial trauma patients, following a venous-injection of 5 mL of 1 mg/mL ICG, using two commercially available NIRS devices.
resultsA significantly slower passage of the dye through the brain of the TBI group was observed in two parameters related to the first ICG inflow into the brain (P=0.04; P=0.01). This is likely related to the reduction of cerebral perfusion following TBI. Significant changes in ICG optical properties minutes after injection (P=0.04) were registered. The acquisition of valid optical data in a clinical environment was challenging.
conclusionsFuture research should analyze abnormalities in the ICG kinetic following brain trauma, test how these values can enhance care in TBI, and adapt the current optical devices to clinical settings. Also, studies on the pattern in changes of ICG optical properties after venous injection can improve the accuracy of the values detected.
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