ArticleNature metabolism2020
Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity.
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Article in Nature metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
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Who cites it
51 citing papers in PubMed, 84 citations in OpenAlex.
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- Adipocyte Expression of O-Glycoprotein Procollagen C-Endopeptidase Enhancer Protein 2 (PCPE2): Mechanisms Linking Fibrosis and Beiging of White Adipose Tissue.bioRxiv : the preprint server for biology · 2026Article
- Perivascular mesenchymal cells instruct ST2+ reparative macrophages to promote endovascular injury-induced neointimal hyperplasia in mice.Nature communications · 2026Article
- From bench to bedside: adipose tissue fibrosis in obesity, anti-diabetic therapies, and bariatric surgery.The Korean journal of internal medicine · 2026Review
- The Multiscale Heterogeneity of Adipose Tissue in Health and Disease.Research (Washington, D.C.) · 2026Review
- The fat-heart entanglement and the role of 'osteopontin mechanics' in cardiometabolic senescence.European journal of clinical investigation · 2026Review
- Canonical NF-κB Pathway as a Central Regulator of Obesity-Associated Inflammation: A Narrative Review.Biomedicines · 2025Review
- Obesity-associated macrophages dictate adipose stem cell ferroptosis and visceral fat dysfunction by propagating mitochondrial fragmentation.Nature communications · 2025Article
- Sex-Specific Impact of 17β-Estradiol and Testosterone Levels on Inflammation and Injury in Acute Myocardial Infarction-Preliminary Results.Biomedicines · 2025Article
- Adipocyte-expressed SIRT3 manipulates carnitine pool to orchestrate metabolic reprogramming and polarization of macrophages.Cell death & disease · 2025Article
- Enhancing adipose tissue plasticity: progenitor cell roles in metabolic health.Nature reviews. Endocrinology · 2025Review
- Distinct adipose progenitor cells emerging with age drive active adipogenesis.Science (New York, N.Y.) · 2025Article
- A panoramic view of cell population dynamics in mammalian aging.Science (New York, N.Y.) · 2025Article
- Association of SII and SIRI with incidence of cardiovascular disease in cardiovascular-kidney-metabolic syndrome: a prospective cohort study.Frontiers in nutrition · 2025Article
- Integrated transcriptomic, proteomic, and metabolomic analysis unveils key roles of protein and nucleic acid interactions in diabetic ulcer pathogenesis.Frontiers in endocrinology · 2025Article
- Article
- Hepatic IRE1α-XBP1 signaling promotes GDF15-mediated anorexia and body weight loss in chemotherapy.The Journal of experimental medicine · 2024Article
- PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels.Nature metabolism · 2024Article
- Single-cell analysis reveals a subpopulation of adipose progenitor cells that impairs glucose homeostasis.Nature communications · 2024Article
- PDGFRβ + cell HIF2α is dispensable for white adipose tissue metabolic remodeling and hepatic lipid accumulation in obese mice.Lipids in health and disease · 2024Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Bo Shan *Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-1675-5809
Mengle Shao *Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-5488-9904
Qianbin ZhangTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Chelsea HeplerTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0001-9938-382X
Vivian A PaschoalTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Spencer D BarnesLyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Lavanya VishvanathTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Yu A AnTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-9678-3382
Lin JiaCenter for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA.
Venkat S MalladiLyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-0144-0564
Douglas W StrandDepartment of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-0746-927X
Olga T GuptaTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Joel K ElmquistCenter for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA.
Dayoung OhTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0003-0687-6479
Rana K GuptaTouchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA. Rana.Gupta@UTSouthwestern.edu.ORCID http://orcid.org/0000-0002-9001-4531
The University of Texas Southwestern Medical Center · USSouthwestern Medical Center · US
Funding
Novel Mechanisms Regulating the Adipocyte-Brain-Hepatocyte AxisP01DK088761 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI HORTON, JAY D. · 2010 to 2019
$17.4MGeneration of Novel Genetic Tools to Study Cellular Heterogeneity in Adipose TissuesRC2DK118620 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI GUPTA, RANA K, SCHERER, PHILIPP E · 2019 to 2023
$7.0MEstablishment and Maintenance of Healthy Adipose Tissue in ObesityR01DK104789 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI GUPTA, RANA K · 2015 to 2024
$3.9MFeed-forward regulation between GPR120 and PPAR gamma - Revision - 1R01DK108773 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI OH, DAYOUNG · 2017 to 2021
$2.2MNotch-mediated 5ARI resistance in human BPHR01DK115477 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI STRAND, DOUGLAS WILLIAM · 2018 to 2022
$1.9MMultifaceted Roles for Pdgfrb+ Perivascular Cells in White Adipose Tissue RemodelingR01DK119163 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI GUPTA, RANA K · 2019 to 2022
$1.8MRole of Hepatocyte TLR4 in Alcohol-induced Steatohepatitis and Insulin ResistanceK01AA024809 · NIAAA · UT SOUTHWESTERN MEDICAL CENTER · PI JIA, LIN · 2017 to 2020
$598kPeritoneal mesothelial cells: Role in obesity and metabolic dysfunctionR03DK101865 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI GUPTA, OLGA THERESA · 2015 to 2017
$572kMultifaceted Roles for Pdgfrb+ Perivascular Cells in White Adipose Tissue RemodelingR56DK119163 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI GUPTA, RANA K · 2018 to 2018
$405kMural Cell Zfp423 in Control of Adipose Remodeling in ObesityF31DK113696 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI HEPLER, CHELSEA · 2017 to 2018
$51kNIAAA NIH HHS K01 AA024809NIDDK NIH HHS F31 DK113696NIDDK NIH HHS P01 DK088761NIDDK NIH HHS R01 DK104789NIDDK NIH HHS R01 DK108773NIDDK NIH HHS R01 DK115477NIDDK NIH HHS R01 DK119163NIDDK NIH HHS R03 DK101865NIDDK NIH HHS R56 DK119163NIDDK NIH HHS RC2 DK118620
Abstract
Chronic low-grade white adipose tissue (WAT) inflammation is a hallmark of metabolic syndrome in obesity. Here, we demonstrate that a subpopulation of mouse WAT perivascular (PDGFRβ
Indexed as
Mesenchymal Stem CellsAdipose Tissue, WhiteAnimalsDiet, High-FatDNA-Binding ProteinsHypoglycemic AgentsInsulinMacrophagesMiceMice, Inbred C57BLObesityReceptor, Platelet-Derived Growth Factor betaSignal TransductionToll-Like Receptor 4Transcription Factor RelATranscription FactorsDNA-Binding ProteinsEbfaz protein, mouseHypoglycemic AgentsInsulinReceptor, Platelet-Derived Growth Factor betaTlr4 protein, mouseToll-Like Receptor 4Transcription Factor RelATranscription Factors
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