ArticleNature chemical biology2021
Production of Tyrian purple indigoid dye from tryptophan in Escherichia coli.
Article in Nature chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 81 citations in OpenAlex.
- Enhancing Production of Tryptophan via Cellulose Utilization by Escherichia coli.Applied biochemistry and biotechnology · 2026Article
- Continuous evolution of a halogenase enzyme with improved solubility and activity for sustainable bioproduction.Nature communications · 2026Article
- Monooxygenase-dehydrogenase cascade for sustained enzymatic remediation of TMA in salmon protein hydrolysates.Applied and environmental microbiology · 2026Article
- Discovery of Antimicrobial Oligoindoles from a Cold-Seep-DerivedMarine drugs · 2025Article
- Engineering artificial biosynthetic pathway enables simultaneous production and in-situ bio-dyeing of indigoids for textiles.Nature communications · 2025Article
- SsDiHal: discovery and engineering of a novel tryptophan dihalogenase.Journal of biological engineering · 2025Article
- Modular pathway engineering for enhanced production ofApplied and environmental microbiology · 2025Article
- De Novo Biosynthesis of Antidepressant Psilocybin in Escherichia coli.Microbial biotechnology · 2025Article
- Self-pigmenting textiles grown from cellulose-producing bacteria with engineered tyrosinase expression.Nature biotechnology · 2025Article
- Isolation, identification, and production optimization of natural functional pigments produced byFrontiers in microbiology · 2025Article
- Advances in the Study of Halogenated Natural Products.Current topics in medicinal chemistry · 2025Review
- PtBGL: a cost-effective alternative to GUS reporter with applications in plant imprint dyeing.Frontiers in plant science · 2025Article
- Article
- Biosynthesis of Halogenated Tryptophans for Protein Engineering Using Genetic Code Expansion.Chembiochem : a European journal of chemical biology · 2024Article
- A modular and synthetic biosynthesis platform for de novo production of diverse halogenated tryptophan-derived molecules.Nature communications · 2024Article
- Modular assembly of an artificially concise biocatalytic cascade for the manufacture of phenethylisoquinoline alkaloids.Nature communications · 2024Article
- Expanding the application of tryptophan: Industrial biomanufacturing of tryptophan derivatives.Frontiers in microbiology · 2023Review
- Production of indigo by recombinant bacteria.Bioresources and bioprocessing · 2023Review
- Discovery of New Phenylacetone Monooxygenase Variants for the Development of Substituted Indigoids through Biocatalysis.International journal of molecular sciences · 2022Article
- Fermentative Production of Halogenated Tryptophan Derivatives with Corynebacterium glutamicum Overexpressing Tryptophanase or Decarboxylase Genes.Chembiochem : a European journal of chemical biology · 2022Article
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Authors and funding
10 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tyrian purple, mainly composed of 6,6'-dibromoindigo (6BrIG), is an ancient dye extracted from sea snails and was recently demonstrated as a biocompatible semiconductor material. However, its synthesis remains limited due to uncharacterized biosynthetic pathways and the difficulty of regiospecific bromination. Here, we introduce an effective 6BrIG production strategy in Escherichia coli using tryptophan 6-halogenase SttH, tryptophanase TnaA and flavin-containing monooxygenase MaFMO. Since tryptophan halogenases are expressed in highly insoluble forms in E. coli, a flavin reductase (Fre) that regenerates FADH
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.