Evidence map›Paper›PMID 33139845›Full record

ArticleMucosal immunology2021

Self and microbiota-derived epitopes induce CD4

Michal P Kuczma, Edyta A Szurek, Anna Cebula, Vu L Ngo, Maciej Pietrzak, Piotr Kraj, Timothy L Denning, Leszek Ignatowicz

Open access · hybridAbstract read
In one paragraph

Article in Mucosal immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. PasteurizedFrontiers in immunology · 2026
    Article
  5. Review
  6. Review
  7. Pregnancy-acquired memory CD4Nature communications · 2025
    Article
  8. Article
  9. Review
  10. Virulence · 2024
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. BATF represses BIM to sustain tolerant T cells in the periphery.The Journal of experimental medicine · 2023
    Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Health and Disease:Research (Washington, D.C.) · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Michal P Kuczma *Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.
Edyta A Szurek *Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.
Anna CebulaInstitute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.
Vu L NgoInstitute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.
Maciej PietrzakMathematical Biosciences Institute, Ohio State University, Columbus, OH, USA.
Piotr KrajDepartment of Biological Sciences, Old Dominion University, Norfolk, VA, USA.
Timothy L DenningInstitute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.
Leszek IgnatowiczInstitute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA. lignatowicz@gsu.edu.
Georgia State University · USOld Dominion University · USThe Ohio State University · US

Funding

National Gnotobiotic Rodent Resource CenterP40OD010995 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ryan B Sartor · 2012 to 2026
$9.7M
Antigenic specificities of intestinal CD4+Foxp3+ T cells.R01AI121151 · NIAID · GEORGIA STATE UNIVERSITY · PI IGNATOWICZ, LESZEK · 2016 to 2020
$1.9M
Role of CD4+T cells in maintenance of intestinal homeostasisR01DK099264 · NIDDK · GEORGIA STATE UNIVERSITY · PI IGNATOWICZ, LESZEK · 2014 to 2017
$1.3M
NIAID NIH HHS R01 AI121151NIDDK NIH HHS R01 DK099264NIH HHS P40 OD010995
6 · The paper itself

Abstract

The physiological role of T cell anergy induction as a key mechanism supporting self-tolerance remains undefined, and natural antigens that induce anergy are largely unknown. In this report, we used TCR sequencing to show that the recruitment of CD4

Indexed as

AnimalsAntigens, BacterialAutoantigensCD4-Positive T-LymphocytesCell DifferentiationCells, CulturedClonal AnergyEpitopes, T-LymphocyteForkhead Transcription FactorsImmune ToleranceLymphocyte ActivationMiceMice, TransgenicMicrobiotaT-Lymphocytes, RegulatoryAntigens, BacterialAutoantigensEpitopes, T-LymphocyteForkhead Transcription FactorsFoxp3 protein, mouse

Identifiers

PMID33139845
PMCPMC7946630
OpenAlexW3095574503

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.