Evidence map›Paper›PMID 33139835›Full record

ArticleScientific reports2020

Primary efficacy of percutaneous microwave ablation of malignant liver tumors: comparison of stereotactic and conventional manual guidance.

Jan Schaible, Lukas Lürken, Philipp Wiggermann, Niklas Verloh, Ingo Einspieler, Florian Zeman, Andreas G Schreyer, Reto Bale, Christian Stroszczynski, Lukas Beyer

Abstract readComparative Study
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Radiological Loco-Regional Treatments for Cholangiocarcinoma: A Systematic Review of the Literature.Liver international : official journal of the International Association for the Study of the Liver · 2026
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  12. Technological Advancements in Interventional Oncology.Diagnostics (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jan SchaibleDepartment of Radiology, University Medical Center Regensburg, 93053, Regensburg, Germany. jan.schaible@ukr.de.
Lukas LürkenDepartment of Radiology, University Medical Center Regensburg, 93053, Regensburg, Germany.ORCID 0000-0002-9716-011X
Philipp WiggermannDepartment of Radiology and Nuclear Medicine, Hospital Braunschweig, Braunschweig, Germany.
Niklas VerlohDepartment of Radiology, University Medical Center Regensburg, 93053, Regensburg, Germany.ORCID 0000-0002-8424-5827
Ingo EinspielerDepartment of Radiology, University Medical Center Regensburg, 93053, Regensburg, Germany.
Florian ZemanCenter for Clinical Studies, University Medical Center Regensburg, Regensburg, Germany.
Andreas G SchreyerDepartment of Radiology, Brandenburg Medical School, Brandenburg, Germany.
Reto BaleDepartment of Microinvasive Therapy (SIP), Medical University Innsbruck, Innsbruck, Austria.
Christian StroszczynskiDepartment of Radiology, University Medical Center Regensburg, 93053, Regensburg, Germany.
Lukas BeyerDepartment of Radiology, University Medical Center Regensburg, 93053, Regensburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we compare the primary efficacy of computed tomography-navigated stereotactic guidance to that of manual guidance for percutaneous microwave ablation of liver malignancies. In total, 221 patients (140, 17, and 64 with hepatocellular carcinoma, cholangiocellular carcinoma, and liver metastases, respectively) with 423 treated liver lesions underwent microwave ablation (MWA). Manual guidance (M) and stereotactic guidance (S) were used for 136 and 287 lesions, respectively. The primary endpoint was the primary efficacy and the secondary endpoint was the radiation dose. A generalised estimating equation was applied to analyse the correlation between the primary efficacy (lesion basis) and the type of guidance, size and location of lesion. The primary efficacy rate was significantly higher in the S-group (84.3%) than in the M-group (75.0%, p = 0.03). Lesion size > 30 mm was negatively correlated with the efficacy rate (odds ratio 0.38; 95% confidence interval 0.20-0.74). Stereotactic guidance was associated with a significantly lower dose length product (p < 0.01). In this retrospective study, percutaneous microwave ablation under stereotactic guidance exhibited significantly greater primary efficacy than conventional manual guidance.

Indexed as

Practice Guidelines as TopicAdultAgedAged, 80 and overCarcinoma, HepatocellularCholangiocarcinomaFemaleHumansLiver NeoplasmsMaleMicrowavesMiddle AgedRadiofrequency AblationRetrospective StudiesStereotaxic TechniquesSurgery, Computer-Assisted

Identifiers

PMID33139835
PMCPMC7608621

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.