ArticleScientific reports2020
Diverse and abundant resistome in terrestrial and aquatic vertebrates revealed by transcriptional analysis.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 28 citations in OpenAlex.
- Metagenomic analysis of UK retail foods finds limited evidence for associations between food production method and antimicrobial resistance gene burden.Microbial genomics · 2026Article
- The gut microbiome and resistome of yellow perch (One health (Amsterdam, Netherlands) · 2024Article
- PandaGUT provides new insights into bacterial diversity, function, and resistome landscapes with implications for conservation.Microbiome · 2023Article
- The universality of eAREs in animal feces suggesting that eAREs function possibly in horizontal gene transfer.Journal of advanced veterinary and animal research · 2023Article
- Article
- Occurrence of Antimicrobial-ResistantAntibiotics (Basel, Switzerland) · 2022Article
- The Bacterial Urban Resistome: Recent Advances.Antibiotics (Basel, Switzerland) · 2022Review
- Whole Genome Sequence-Based Prediction of Resistance Determinants in High-Level Multidrug-ResistantMicroorganisms · 2020Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite increasing evidence that antibiotic resistant pathogens are shared among humans and animals, the diversity, abundance and patterns of spread of antibiotic resistance genes (ARGs) in wildlife remains unclear. We identified 194 ARGs associated with phenotypic resistance to 13 types of antibiotic in meta-transcriptomic data generated from a broad range of lower vertebrates residing in both terrestrial and aquatic habitats. These ARGs, confirmed by PCR, included those that shared high sequence similarity to clinical isolates of public health concern. Notably, the lower vertebrate resistome varied by ecological niche of the host sampled. The resistomes in marine fish shared high similarity and were characterized by very high abundance, distinct from that observed in other habitats. An assessment of ARG mobility found that ARGs in marine fish were frequently co-localized with mobile elements, indicating that they were likely spread by horizontal gene transfer. Together, these data reveal the remarkable diversity and transcriptional levels of ARGs in lower vertebrates, and suggest that these wildlife species might play an important role in the global spread of ARGs.
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Registered trials
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