ArticleTranslational psychiatry2020
Analysis of brain networks and fecal metabolites reveals brain-gut alterations in premenopausal females with irritable bowel syndrome.
Article in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
- Distinct psychophysiological biomarkers and risk stratification models for irritable bowel syndrome with constipation (IBS-C) and diarrhea (IBS-D).Scientific reports · 2026Article
- Gut-Brain Connection: Deciphering Causal Pathways Between Gut Microbiota and Neuroimaging Profiles Through Mendelian Randomization.Food science & nutrition · 2026Article
- Brain-body interactions in systemic diseases: a survey from an imaging perspective.MedScience · 2026Review
- Social bonds and health: exploring the impact of social relations on oxytocin and brain-gut communication in shaping obesity.Gut microbes · 2025Article
- Exploring the effects of faecal microbiota transplantation on cognitive function: A review of clinical trials.Brain, behavior, & immunity - health · 2025Review
- Article
- Microbial orchestration of neuroimmune crosstalk: from homeostasis to disease.Frontiers in immunology · 2025Review
- Identification of neural alterations in patients with Crohn's disease with a novel multiparametric brain MRI-based radiomics model.Insights into imaging · 2024Article
- Stress-Resilience Impacts Psychological Wellbeing: Evidence from Brain-Gut Microbiome Interactions.Nature. Mental health · 2024Article
- Discrimination exposure impacts unhealthy processing of food cues: crosstalk between the brain and gut.Nature. Mental health · 2023Article
- Improved psychosocial measures associated with physical activity may be explained by alterations in brain-gut microbiome signatures.Scientific reports · 2023Article
- Gut Microbiome-Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders.ACS chemical neuroscience · 2023Review
- Exploration of associations among dietary tryptophan, microbiome composition and function, and symptom severity in irritable bowel syndrome.Neurogastroenterology and motility · 2023Article
- A multi-omic brain gut microbiome signature differs between IBS subjects with different bowel habits.Neuropharmacology · 2023Review
- Effects of Cyclosporine A and Adalimumab on the expression profiles histaminergic system-associated genes and microRNAs regulating these genes in HaCaT cells.Cell cycle (Georgetown, Tex.) · 2022Article
- Structural and functional neuroimaging of the effects of the gut microbiome.European radiology · 2022Review
- Brain Functional Network and Amino Acid Metabolism Association in Females with Subclinical Depression.International journal of environmental research and public health · 2022Article
- Gut bless you: The microbiota-gut-brain axis in irritable bowel syndrome.World journal of gastroenterology · 2022Review
- Aberrant resting-state functional connectivity and topological properties of the subcortical network in functional dyspepsia patients.Frontiers in molecular neuroscience · 2022Article
- Global Research Trends in Irritable Bowel Syndrome: A Bibliometric and Visualized Study.Frontiers in medicine · 2022Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Alterations in brain-gut-microbiome (BGM) interactions have been implicated in the pathogenesis of irritable bowel syndrome (IBS). Here, we apply a systems biology approach, leveraging neuroimaging and fecal metabolite data, to characterize BGM interactions that are driving IBS pathophysiology. Fecal samples and resting state fMRI images were obtained from 138 female subjects (99 IBS, 39 healthy controls (HCs)). Partial least-squares discriminant analysis (PLS-DA) was conducted to explore group differences, and partial correlation analysis explored significantly changed metabolites and neuroimaging data. All correlational tests were performed controlling for age, body mass index, and diet; results are reported after FDR correction, with q < 0.05 as significant. Compared to HCs, IBS showed increased connectivity of the putamen with regions of the default mode and somatosensory networks. Metabolite pathways involved in nucleic acid and amino acid metabolism differentiated the two groups. Only a subset of metabolites, primarily amino acids, were associated with IBS-specific brain changes, including tryptophan, glutamate, and histidine. Histidine was the only metabolite positively associated with both IBS-specific alterations in brain connectivity. Our findings suggest a role for several amino acid metabolites in modulating brain function in IBS. These metabolites may alter brain connectivity directly, by crossing the blood-brain-barrier, or indirectly through peripheral mechanisms. This is the first study to integrate both neuroimaging and fecal metabolite data supporting the BGM model of IBS, building the foundation for future mechanistic studies on the influence of gut microbial metabolites on brain function in IBS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.