Evidence map›Paper›PMID 33139704›Full record

ArticleNature communications2020

Full genome viral sequences inform patterns of SARS-CoV-2 spread into and within Israel.

Danielle Miller, Michael A Martin, Noam Harel, Omer Tirosh, Talia Kustin, Moran Meir, Nadav Sorek, Shiraz Gefen-Halevi, Sharon Amit, Olesya Vorontsov and 9 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 2 syntheses or guidelines pooled it, 159 citations in OpenAlex.

  1. Pooled it
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  18. Reply to "SARS-CoV-2 reinfection or persistence among immunodeficient patients".The journal of allergy and clinical immunology. In practice · 2023
    Article
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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 2 countries.

Danielle MillerThe Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
Michael A MartinDepartment of Biology, Emory University, Atlanta, GA, USA.ORCID 0000-0002-9689-4066
Noam HarelThe Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
Omer TiroshThe Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
Talia KustinThe Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
Moran MeirThe Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
Nadav SorekMicrobiology Laboratory, Assuta Ashdod University-Affiliated Hospital, Ashdod, Israel.
Shiraz Gefen-HaleviClinical Microbiology Laboratory, Sheba Medical Center, Ramat-Gan, Israel.
Sharon AmitClinical Microbiology Laboratory, Sheba Medical Center, Ramat-Gan, Israel.
Olesya VorontsovClinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Avraham ShaagClinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Dana WolfClinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Avi PeretzThe Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Yonat Shemer-AvniClinical Virology Laboratory, Soroka Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Diana Roif-KaminskyMicrobiology Division, Barzilai University Medical Center, Ashkelon, Israel.
Naama M KopelmanDepartment of Computer Science, Holon Institute of Technology, Holon, Israel.
Amit HuppertBio-statistical and Bio-mathematical Unit, The Gertner Institute for Epidemiology and Health Policy Research, Chaim Sheba Medical Center, 52621, Tel Hashomer, Israel.
Katia KoelleDepartment of Biology, Emory University, Atlanta, GA, USA.
Adi SternThe Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel. sternadi@tauex.tau.ac.il.ORCID 0000-0002-2919-3542
Tel Aviv University · ILHadassah Medical Center · ILEmory University · USSheba Medical Center · ILAssuta Medical Center · ILBar-Ilan University · ILBarzilai Medical Center · ILBen-Gurion University of the Negev · ILHolon Institute of Technology · IL

Funding

MIDAS Coordination CenterU24GM132013 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOCHHEISER, HARRY S · 2019 to 2023
$8.1M
NIAID NIH HHS HHSN272201400004CNIGMS NIH HHS U24 GM132013
6 · The paper itself

Abstract

Full genome sequences are increasingly used to track the geographic spread and transmission dynamics of viral pathogens. Here, with a focus on Israel, we sequence 212 SARS-CoV-2 sequences and use them to perform a comprehensive analysis to trace the origins and spread of the virus. We find that travelers returning from the United States of America significantly contributed to viral spread in Israel, more than their proportion in incoming infected travelers. Using phylodynamic analysis, we estimate that the basic reproduction number of the virus was initially around 2.5, dropping by more than two-thirds following the implementation of social distancing measures. We further report high levels of transmission heterogeneity in SARS-CoV-2 spread, with between 2-10% of infected individuals resulting in 80% of secondary infections. Overall, our findings demonstrate the effectiveness of social distancing measures for reducing viral spread.

Indexed as

AdolescentAdultAgedAged, 80 and overBase SequenceBasic Reproduction NumberBetacoronavirusChildChild, PreschoolCommunicable Diseases, ImportedCoronavirus InfectionsCOVID-19FemaleGenome, ViralHumansInfantRNA, Viral

Identifiers

PMID33139704
PMCPMC7606475
OpenAlexW3096084589

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.