Evidence map›Paper›PMID 33139690›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2020

Role of Sevoflurane on Natural Killer Group 2, Member D-Mediated Immune Response in Non-Small-Cell Lung Cancer: An In Vitro Study.

Soeun Jeon, Hae-Kyu Kim, Jae-Young Kwon, Seung-Hoon Baek, Hyun-Su Ri, Ho Jung Choi, Hae-Ryung Cho, Young Shin Lee, Joo-Young Kim, Jinsil Kim and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical science monitor : international medical journal of experimental and clinical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Local anesthetics elicit immune-dependent anticancer effects.Journal for immunotherapy of cancer · 2022
    Article
  7. Article
  8. Review
  9. Effect of Inhalation Anesthetics on Tumor Metastasis.Technology in cancer research & treatment
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Soeun JeonDepartment of Anesthesia and Pain Medicine, Pusan National University, School of Medicine, Busan, South Korea.
Hae-Kyu KimDepartment of Anesthesia and Pain Medicine, Pusan National University, School of Medicine, Busan, South Korea.
Jae-Young KwonDepartment of Anesthesia and Pain Medicine, Pusan National University, School of Medicine, Busan, South Korea.
Seung-Hoon BaekDepartment of Anesthesia and Pain Medicine, Pusan National University, School of Medicine, Busan, South Korea.
Hyun-Su RiDepartment of Anesthesia and Pain Medicine, Pusan National University Yangsan Hospital, Pusan National University, School of Medicine, Yangsan, South Korea.
Ho Jung ChoiDepartment of Biochemistry, Pusan National University, School of Medicine, Yangsan, South Korea.
Hae-Ryung ChoDepartment of Biochemistry, Pusan National University, School of Medicine, Yangsan, South Korea.
Young Shin LeeDepartment of Biochemistry, Pusan National University, School of Medicine, Yangsan, South Korea.
Joo-Young KimResearch Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea.
Jinsil KimDepartment of Anesthesia and Pain Medicine, Pusan National University, School of Medicine, Busan, South Korea.
Jaeho BaeDepartment of Biochemistry, Pusan National University, School of Medicine, Yangsan, South Korea.
Hyeon-Jeong LeeDepartment of Anesthesia and Pain Medicine, Pusan National University, School of Medicine, Busan, South Korea.
Pusan National University · KRPusan National University Yangsan Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND The purpose of this study was to investigate the effects of sevoflurane on cancer immunosurveillance and metastasis in non-small-cell lung cancer (NSCLC). MATERIAL AND METHODS NCI-H23 cells, a human NSCLC cell line, were incubated with or without sevoflurane at the concentrations of 0, 12.5, 25, 50, 100, and 200 μM for 6 h. Cell viability, the expression of natural killer group 2, member D ligands (NKG2D ligands: UL16-binding proteins 1-3 [ULBP1-3] and major histocompatibility complex class I chain-related molecules A/B [MICA/B]), the expression of matrix metalloproteinases (MMPs), NK cell-mediated cytotoxicity, and cancer cell migration were measured. RESULTS At 12.5, 25, 50, and 100 μM, sevoflurane increased the expression of NKG2D ligands (ULBP2-3 and MICA, ULBP1-3, ULBP1-3, and ULBP1, respectively). Sevoflurane decreased the expression of NKG2D ligands at 200 μM (MICA/B). NK cell-mediated lysis of NCI-H23 cells at 200 μM sevoflurane was significantly reduced compared with the control (P=0.025; target cell: effect cell=1: 10). Sevoflurane increased the expression of MMP-1, -2, and -9 and increased cell migration in NCI-H23 cells at 50, 100, and 200 μM (P=0.001, 0.035, and 0.039, respectively, compared with the control after 18 h of wound formation). CONCLUSIONS Sevoflurane could suppress NKG2D-mediated NK cell cytotoxicity and increased expression of MMPs and migration in NCI-H23 cells. Further research is needed to determine the effects of sevoflurane on cancer immunosurveillance and metastasis in NSCLC.

Indexed as

Carcinoma, Non-Small-Cell LungCell Line, TumorCell MovementCell SurvivalCytotoxicity, ImmunologicGene Expression Regulation, NeoplasticHumansImmunityLigandsLung NeoplasmsMatrix MetalloproteinasesNK Cell Lectin-Like Receptor Subfamily KRNA, MessengerSevofluraneWound HealingLigandsMatrix MetalloproteinasesNK Cell Lectin-Like Receptor Subfamily KRNA, MessengerSevoflurane

Identifiers

PMID33139690
PMCPMC7648410
OpenAlexW3085500865

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.