ArticleInternational journal of environmental research and public health2020
Cohort Profile: ZOE 2.0-A Community-Based Genetic Epidemiologic Study of Early Childhood Oral Health.
Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis on early-childhood-caries global data.BMC oral health · 2024Pooled it
- Genomic basis of developmental defects of enamel and sex-specific effects.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Article
- Genome-wide association study of childhood B-cell acute lymphoblastic leukemia reveals novel African ancestry-specific susceptibility loci.Nature communications · 2025Article
- Multiancestry Genome-Wide Association Study of Early Childhood Caries.Journal of dental research · 2025Article
- Improvement of parents' oral health knowledge by a school-based oral health promotion for parents of preschool children: a prospective observational study.BMC oral health · 2023Observational
- Comprehensive evaluation of methods for differential expression analysis of metatranscriptomics data.Briefings in bioinformatics · 2023Article
- Selenomonas sputigena acts as a pathobiont mediating spatial structure and biofilm virulence in early childhood caries.Nature communications · 2023Article
- BZINB Model-Based Pathway Analysis and Module Identification Facilitates Integration of Microbiome and Metabolome Data.Microorganisms · 2023Article
- BZINB model-based pathway analysis and module identification facilitates integration of microbiome and metabolome data.bioRxiv : the preprint server for biology · 2023Article
- Guardians' Self-Reported Fair/Poor Oral Health Is Associated with Their Young Children's Fair/Poor Oral Health and Clinically Determined Dental Caries Experience.International journal of environmental research and public health · 2022Article
- Children's oral health-related behaviours and early childhood caries: A latent class analysis.Community dentistry and oral epidemiology · 2022Article
- PARTITIONING AROUND MEDOIDS CLUSTERING AND RANDOM FOREST CLASSIFICATION FOR GIS-INFORMED IMPUTATION OF FLUORIDE CONCENTRATION DATA.The annals of applied statistics · 2022Article
- A Web-Based Rendering Application for Communicating Dental Conditions.Healthcare (Basel, Switzerland) · 2021Article
- Metabolomics Insights in Early Childhood Caries.Journal of dental research · 2021Article
- An Automated Machine Learning Classifier for Early Childhood Caries.Pediatric dentistry · 2021Article
- Guardian Reports of Children's Sub-optimal Oral Health Are Associated With Clinically Determined Early Childhood Caries, Unrestored Caries Lesions, and History of Toothaches.Frontiers in public health · 2021Article
- Improved Metabolite Prediction Using Microbiome Data-Based Elastic Net Models.Frontiers in cellular and infection microbiology · 2021Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
Early childhood caries (ECC) is an aggressive form of dental caries occurring in the first five years of life. Despite its prevalence and consequences, little progress has been made in its prevention and even less is known about individuals' susceptibility or genomic risk factors. The genome-wide association study (GWAS) of ECC ("ZOE 2.0") is a community-based, multi-ethnic, cross-sectional, genetic epidemiologic study seeking to address this knowledge gap. This paper describes the study's design, the cohort's demographic profile, data domains, and key oral health outcomes. Between 2016 and 2019, the study enrolled 8059 3-5-year-old children attending public preschools in North Carolina, United States. Participants resided in 86 of the state's 100 counties and racial/ethnic minorities predominated-for example, 48% (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.