Evidence map›Paper›PMID 33139595›Full record

ReviewInternational journal of environmental research and public health2020

Environmental Issues and Neurological Manifestations Associated with COVID-19 Pandemic: New Aspects of the Disease?

Luigi Bellocchio, Ioana Roxana Bordea, Andrea Ballini, Felice Lorusso, Denisa Hazballa, Ciro Gargiulo Isacco, Giuseppina Malcangi, Alessio Danilo Inchingolo, Gianna Dipalma, Francesco Inchingolo and 3 more

Open access · goldAbstract readEditorialReview
In one paragraph

Review in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Pooled it
  5. Observational
  6. Review
  7. Review
  8. Article
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  12. Article
  13. Central nervous system outcomes of COVID-19.Translational research : the journal of laboratory and clinical medicine · 2022
    Review
  14. Review
  15. Article
  16. Autism Spectrum Disorder and Prenatal or Early Life Exposure to Pesticides: A Short Review.International journal of environmental research and public health · 2021
    Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 4 countries.

Luigi BellocchioINSERM, U1215 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, University of Bordeaux, 33000 Bordeaux, France.
Ioana Roxana BordeaDepartment of Oral Rehabilitation, Faculty of Dentistry, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Andrea BalliniDepartment of Biosciences, Biotechnologies and Biopharmaceutics, Campus Universitario "Ernesto Quagliariello" University of Bari "Aldo Moro", 70125 Bari, Italy.ORCID 0000-0001-8758-1415
Felice LorussoDepartment of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-2660-9231
Denisa HazballaKongresi Elbasanit, Rruga: Aqif Pasha, 3001 Elbasan, Albania.
Ciro Gargiulo IsaccoEmbryology and Regenerative Medicine and Immunology at Pham Chau Trinh University of Medicine Hoi An, Ho Chi Minh 70000, Vietnam.
Giuseppina MalcangiDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70121 Bari, Italy.
Alessio Danilo InchingoloDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70121 Bari, Italy.
Gianna DipalmaDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70121 Bari, Italy.
Francesco InchingoloDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70121 Bari, Italy.
Prisco PiscitelliStaff UNESCO Chair on Health Education and Sustainable Development, Federico II University, 80138 Naples, Italy.ORCID 0000-0003-4556-6182
Giancarlo LogroscinoDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, 70121 Bari, Italy.
Alessandro MianiDepartment of Environmental Sciences and Policy, University of Milan, 20068 Milan, Italy.
University of Bari Aldo Moro · ITFederico II University Hospital · ITIuliu Hațieganu University of Medicine and Pharmacy · ROUniversité de Bordeaux · FRUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Chieti-Pescara · ITUniversity of Elbasan · ALUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus (SARS-CoV-2) emerged in China in December 2019 and rapidly caused a global health pandemic. Current evidence seems to suggest a possible link with ecosystem disequilibrium and even air pollution. The primary manifestations affect respiratory and circulatory systems, but neurological features are also being reported through case reports and case series. We summarize neurological symptoms and complications associated with COVID-19. We have searched for original articles published in PubMed/Medline, PubMed Central and Google Scholar using the following keywords: "COVID-19", "Coronavirus", "pandemic", "SARS-COV-2", "neurology", "neurological", "complications" and "manifestations". We found around 1000 publications addressing the issue of neurological conditions associated with COVID-19 infection. Amongst those, headache and dizziness are the most common reported symptoms followed by encephalopathy and delirium, while the most frequent complications are cerebrovascular accidents, Guillain-Barré syndrome, acute transverse myelitis, and acute encephalitis. Specific symptoms affecting the peripheral nervous system such as hyposmia and dysgeusia are the most common manifestations recorded in the selected studies. Interestingly, it was noted that these kinds of neurological symptoms might precede the typical features, such as fever and cough, in COVID patients. Neurological symptoms and complications associated with COVID-19 should be considered as a part of the clinical features of this novel global pandemic.

Indexed as

PandemicsBetacoronavirusChinaComorbidityCoronavirus InfectionsCOVID-19DizzinessDysgeusiaHeadacheHumansNervous System DiseasesPneumonia, ViralSARS-CoV-2COVID-19deliriumencephalitisenvironmentneurological symptomsstroke

Identifiers

PMID33139595
PMCPMC7663018
OpenAlexW3096468870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.