Evidence map›Paper›PMID 33139586›Full record

ArticleBlood research2020

Prognostic value of TNF-a-308 and IFN-g-874 single nucleotide polymorphisms and their plasma levels in patients with aplastic anemia.

Saurabh Shukla, Anil Kumar Tripathi, Shailendra Prasad Verma, Nidhi Awasthi

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Saurabh ShuklaDepartment of Clinical Hematology, King George's Medical University, Lucknow, India.
Anil Kumar TripathiDepartment of Clinical Hematology, King George's Medical University, Lucknow, India.
Shailendra Prasad VermaDepartment of Clinical Hematology, King George's Medical University, Lucknow, India.
Nidhi AwasthiDepartment of Clinical Hematology, King George's Medical University, Lucknow, India.
King George's Medical University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAplastic anemia (AA), an unusual hematological disease, is characterized by hypoplasia of the bone marrow and failure to form blood cells of all three lineages resulting in pancytopenia. This study aimed to investigate TNF-a-308 and IFN-g-874 gene polymorphisms and their respective plasma protein levels in patients with AA and healthy controls.

methodsTwo hundred and forty individuals were included in this study; the case group comprised 120 AA patients, while 120 healthy individuals served as controls. Genotyping was performed using the PCR-restriction length fragment polymorphism method and TNF-a-308 and IFN-g-874 plasma levels were evaluated using an ELISA kit.

resultsThere was a significantly higher prevalence of the IFN-g-874 genotype in patients with AA than in healthy controls, while the TNF-a-308 genotype was associated with lower risk of developing AA. Furthermore, the levels of both TNF-a-308 and IFN-g-874 were higher in the plasma of AA patients.

conclusionOur findings suggest that the IFN-g-874 genotype may be a greater risk factor in the causation of AA, whereas the TNF-a-308 genotype has a protective role in the North Indian population.

Indexed as

Aplastic anemiaELISAIFN-g-874PCR-RFLPPolymorphismTNF-a-308

Identifiers

PMID33139586
PMCPMC7784124
OpenAlexW3097065350

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.