ArticleProceedings of the National Academy of Sciences of the United States of America2020
An evolutionarily acquired microRNA shapes development of mammalian cortical projections.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Longitudinal Analysis of Peripheral MicroRNA Expression and Depressive Symptom Severity Change in a Community Cohort.Epigenomes · 2026Article
- miRNA regulation in brain tissue space: the 3'UTR perspective.RNA (New York, N.Y.) · 2026Review
- Article
- miR-193b-365 microcluster downstream ofiScience · 2024Article
- Involvement of extracellular vesicle microRNA clusters in developing healthy and Rett syndrome brain organoids.Cellular and molecular life sciences : CMLS · 2024Article
- Making Ramón y Cajal proud: Development of cell identity and diversity in the cerebral cortex.Neuron · 2024Review
- Cbln1 Directs Axon Targeting by Corticospinal Neurons Specifically toward Thoraco-Lumbar Spinal Cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents.Translational psychiatry · 2023Article
- Evolution of genetic mechanisms regulating cortical neurogenesis.Developmental neurobiology · 2022Review
- Spinal cord injury: a study protocol for a systematic review and meta-analysis of microRNA alterations.Systematic reviews · 2022Article
- miR-137 and miR-122, two outer subventricular zone non-coding RNAs, regulate basal progenitor expansion and neuronal differentiation.Cell reports · 2022Article
- Translational control in cortical development.Frontiers in neuroanatomy · 2022Article
- miR-409-3p repressesFrontiers in neuroscience · 2022Article
- Evolving features of human cortical development and the emerging roles of non-coding RNAs in neural progenitor cell diversity and function.Cellular and molecular life sciences : CMLS · 2021Article
- Human brain evolution: Emerging roles for regulatory DNA and RNA.Current opinion in neurobiology · 2021Review
- MicroRNA regulation of prefrontal cortex development and psychiatric risk in adolescence.Seminars in cell & developmental biology · 2021Review
- MicroRNAs Instruct and Maintain Cell Type Diversity in the Nervous System.Frontiers in molecular neuroscience · 2021Review
- Perspective on adolescent psychiatric illness and emerging role of microRNAs as biomarkers of risk.Journal of psychiatry & neuroscience : JPNArticle
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
Abstract
The corticospinal tract is unique to mammals and the corpus callosum is unique to placental mammals (eutherians). The emergence of these structures is thought to underpin the evolutionary acquisition of complex motor and cognitive skills. Corticospinal motor neurons (CSMN) and callosal projection neurons (CPN) are the archetypal projection neurons of the corticospinal tract and corpus callosum, respectively. Although a number of conserved transcriptional regulators of CSMN and CPN development have been identified in vertebrates, none are unique to mammals and most are coexpressed across multiple projection neuron subtypes. Here, we discover 17 CSMN-enriched microRNAs (miRNAs), 15 of which map to a single genomic cluster that is exclusive to eutherians. One of these, miR-409-3p, promotes CSMN subtype identity in part via repression of LMO4, a key transcriptional regulator of CPN development. In vivo, miR-409-3p is sufficient to convert deep-layer CPN into CSMN. This is a demonstration of an evolutionarily acquired miRNA in eutherians that refines cortical projection neuron subtype development. Our findings implicate miRNAs in the eutherians' increase in neuronal subtype and projection diversity, the anatomic underpinnings of their complex behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.