ArticleProceedings of the National Academy of Sciences of the United States of America2020
CEACAMs serve as toxin-stimulated receptors for enterotoxigenic
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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0cells of the map it votes in
30citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 39 citations in OpenAlex.
- Endocytic CEACAM receptor loss and lack of positive selection in CEACAM1 of birds and snakes indicate absence of pathogen-CEACAM1 interactions in some reptiles.Research square · 2026Article
- Pathogenesis of adherent-invasiveGut microbes · 2025Article
- An Asset for Food Safety: The Knowledge Behind the Physiological Alterations Induced by ETEC Enterotoxins.Foods (Basel, Switzerland) · 2025Review
- Intestinal inflammation induced by heat-labile toxin-producing enterotoxigenic E: Coli infection and impact on immune responses in an experimental human challenge model.PLoS neglected tropical diseases · 2025Article
- Building a Broader Understanding of EnterotoxigenicOpen forum infectious diseases · 2025Article
- Spatial transcriptomics delineates potential differences in intestinal phenotypes of cardiac and classical necrotizing enterocolitis.iScience · 2025Article
- Safety and immunogenicity in humans of enterotoxigenic Escherichia coli double mutant heat-labile toxin administered intradermally.NPJ vaccines · 2025Article
- Safety and immunogenicity of a recombinant double-mutant heat-labile toxin derived from enterotoxigenicFrontiers in bacteriology · 2025Article
- Current investigation of carcinoembryonic antigen cell adhesion molecule (CEACAM) biology summary of the 32nd CEA symposium: 20-23 September 2024. Würzburg, Germany.European journal of clinical investigation · 2024Article
- Evolution of CEACAM pathogen decoy receptors in primates.European journal of clinical investigation · 2024Article
- Host-derived CEACAM-laden vesicles engage enterotoxigenicProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Host-derived CEACAM-laden vesicles engage enterotoxigenicbioRxiv : the preprint server for biology · 2024Article
- Effect of knocking out mouseAmerican journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Dietary glycerides of valerate ameliorate diarrhea and impact intestinal physiology and serum biomarkers in weaned piglets infected with enterotoxigenic Escherichia coli F18.Journal of animal science · 2024Article
- The Controlled Human Infection Model for Enterotoxigenic Escherichia coli.Current topics in microbiology and immunology · 2024Review
- Bacterial lipopolysaccharide inhibits colonic carrier-mediated uptake of thiamin pyrophosphate: roles for TLR4 receptor and NF-κB/P38/JNK signaling pathway.American journal of physiology. Cell physiology · 2023Article
- Article
- CEACAMS 1, 5, and 6 in disease and cancer: interactions with pathogens.Genes & cancer · 2023Review
- Interactions of pathogenicFrontiers in immunology · 2023Review
- Tumor necrosis factor α impedes colonic thiamin pyrophosphate and free thiamin uptake: involvement of JNK/ERKAmerican journal of physiology. Cell physiology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Alaullah SheikhDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-2972-6978
Brunda TumalaDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO 63110.
Tim J VickersDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO 63110.
David AlvaradoDepartment of Medicine, Division of Gastroenterology, Washington University School of Medicine, Saint Louis, MO 63110.ORCID 0000-0001-8748-0761
Matthew A CiorbaDepartment of Medicine, Division of Gastroenterology, Washington University School of Medicine, Saint Louis, MO 63110.ORCID 0000-0002-7656-0982
Taufiqur Rahman BhuiyanInternational Centre for Diarrhoeal Disease Research, Bangladesh (ICDDRB), Dhaka, Bangladesh.ORCID 0000-0003-3755-4763
Firdausi QadriInternational Centre for Diarrhoeal Disease Research, Bangladesh (ICDDRB), Dhaka, Bangladesh.
Bernhard B SingerInstitute of Anatomy, Medical Faculty, University Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0002-2213-6000
James M FleckensteinDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO 63110; jflecken@wustl.edu.ORCID 0000-0002-1148-697X
Washington University in St. Louis · USInternational Centre for Diarrhoeal Disease Research · BDUniversity of Duisburg-Essen · DE
Funding
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MWashington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4MWashington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8MNovel Antigen Identification for an Enterotoxigenic E. coli VaccineR01AI089894 · NIAID · WASHINGTON UNIVERSITY · PI Zachary T. Berndsen, James Michael Fleckenstein · 2010 to 2026
$7.4MMolecular Microbiology of Enterotoxigenic E. coli Pathogen-Host InteractionsR01AI126887 · NIAID · WASHINGTON UNIVERSITY · PI FLECKENSTEIN, JAMES MICHAEL · 2016 to 2020
$1.6MMolecular Pathogenesis of Enterotoxigenic Escherichia coli InfectionsI01BX004825 · VA · ST. LOUIS VA MEDICAL CENTER · PI FLECKENSTEIN, JAMES MICHAEL · 2020 to 2024
–BLRD VA I01 BX004825NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NIAID NIH HHS R01 AI089894NIAID NIH HHS R01 AI126887NIDDK NIH HHS P30 DK052574
Abstract
The enterotoxigenic
Indexed as
Adhesins, BacterialAntigens, CDBacterial ToxinsCaco-2 CellsCell Adhesion MoleculesDiarrheaEnterotoxigenic Escherichia coliEpithelial CellsEscherichia coli InfectionsGPI-Linked ProteinsHeLa CellsHost-Pathogen InteractionsHumansIntestinal MucosaTranscriptomeAdhesins, BacterialAntigens, CDBacterial ToxinsCEACAM6 protein, humanCell Adhesion MoleculesGPI-Linked ProteinsCEACAMdiarrheaenterotoxin
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.