ArticleProceedings of the National Academy of Sciences of the United States of America2020
Neural control of rapid binocular eye movements: Saccade-vergence burst neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- A new oculomotor model demystifies "Remarkable Saccades".Vision research · 2026Article
- Neural Innervation of Cyclovertical Extraocular Muscles During Asymmetric Vertical Vergence.Investigative ophthalmology & visual science · 2026Article
- Cross-species lesion mapping links a midbrain circuit to vergence dysfunction.Brain : a journal of neurology · 2026Article
- Precerebellar paramedian tract cell groups connections: I. Oculomotor internuclear projections.Brain structure & function · 2025Article
- Neural Control of Vergence and Ocular Accommodation.Annual review of vision science · 2025Review
- Subsets of extraocular motoneurons produce kinematically distinct saccades during hunting and exploration.Current biology : CB · 2025Article
- Kinematically distinct saccades are used in a context-dependent manner by larval zebrafish.Current biology : CB · 2024Article
- Brainstem sources of input to the central mesencephalic reticular formation in the macaque.Experimental brain research · 2023Article
- Emerging order of anomalous eye movements with progressive drowsiness.Journal of vision · 2023Article
- Receded near point of convergence as a predictor of mild cognitive impairment in the general geriatric population: results from a population-based study.International journal of ophthalmology · 2023Article
- Is the central mesencephalic reticular formation a purely horizontal gaze center?Brain structure & function · 2022Article
- Large-scale cortico-cerebellar computations for horizontal and vertical vergence in humans.Scientific reports · 2022Article
- Intrinsic bursts facilitate learning of Lévy flight movements in recurrent neural network models.Scientific reports · 2022Article
- Input and output organization of the mesodiencephalic junction for cerebro-cerebellar communication.Journal of neuroscience research · 2022Article
- A Novel Tectal/Pretectal Population of Premotor Lens Accommodation Neurons.Investigative ophthalmology & visual science · 2022Article
- Alteration of Degree Centrality in Adolescents With Early Blindness.Frontiers in human neuroscience · 2022Article
- Stochastic Physiological Gaze-Evoked Nystagmus With Slow Centripetal Drift During Fixational Eye Movements at Small Gaze Eccentricities.Frontiers in human neuroscience · 2022Article
- A distributed saccade-associated network encodes high velocity conjugate and monocular eye movements in the zebrafish hindbrain.Scientific reports · 2021Article
- Cerebellar projections to the macaque midbrain tegmentum: Possible near response connections.Visual neuroscience · 2021Article
- Neural control of rapid binocular eye movements: Saccade-vergence burst neurons.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
During normal viewing, we direct our eyes between objects in three-dimensional (3D) space many times a minute. To accurately fixate these objects, which are usually located in different directions and at different distances, we must generate eye movements with appropriate versional and vergence components. These combined saccade-vergence eye movements result in disjunctive saccades with a vergence component that is much faster than that generated during smooth, symmetric vergence eye movements. The neural control of disjunctive saccades is still poorly understood. Recent anatomical studies suggested that the central mesencephalic reticular formation (cMRF), located lateral to the oculomotor nucleus, contains premotor neurons potentially involved in the neural control of these eye movements. We have therefore investigated the role of the cMRF in the control of disjunctive saccades in trained rhesus monkeys. Here, we describe a unique population of cMRF neurons that, during disjunctive saccades, display a burst of spikes that are highly correlated with vergence velocity. Importantly, these neurons show no increase in activity for either conjugate saccades or symmetric vergence. These neurons are termed saccade-vergence burst neurons (SVBNs) to maintain consistency with modeling studies that proposed that such a class of neuron exists to generate the enhanced vergence velocities observed during disjunctive saccades. Our results demonstrate the existence and characteristics of SVBNs whose activity is correlated solely with the vergence component of disjunctive saccades and, based on modeling studies, are critically involved in the generation of the disjunctive saccades required to view objects in our 3D world.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.