Evidence map›Paper›PMID 33139519›Full record

ArticleScience translational medicine2020

Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19.

Yu Zuo, Shanea K Estes, Ramadan A Ali, Alex A Gandhi, Srilakshmi Yalavarthi, Hui Shi, Gautam Sule, Kelsey Gockman, Jacqueline A Madison, Melanie Zuo and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 390 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
390citing papers in PubMed, 6 pooled it
13.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

390 citing papers in PubMed, 6 syntheses or guidelines pooled it, 635 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Effect of vitamin DClinics (Sao Paulo, Brazil) · 2024
    Trial
  8. Trial
  9. Article
  10. Association of EndometrialBiomedicines · 2026
    Article
  11. Review
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330 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 2 countries.

Yu ZuoDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-6721-7755
Shanea K EstesDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Ramadan A AliDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Alex A GandhiDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Srilakshmi YalavarthiDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Hui ShiDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-3574-8807
Gautam SuleDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Kelsey GockmanDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Jacqueline A MadisonDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-1745-8133
Melanie ZuoDivision of Geriatric and Palliative Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Vinita YadavDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Jintao WangDivision of Intramural Research, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA.
Wrenn WoodardMichigan Clinical Research Unit, University of Michigan, Ann Arbor, MI 48109, USA.
Sean P LezakMichigan Clinical Research Unit, University of Michigan, Ann Arbor, MI 48109, USA.
Njira L LugogoDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Stephanie A SmithDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-4895-6215
James H MorrisseyDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-1570-1569
Yogendra KanthiDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. yogen.kanthi@nih.gov jsknight@umich.edu.ORCID 0000-0002-5660-5194
Jason S KnightDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. yogen.kanthi@nih.gov jsknight@umich.edu.ORCID 0000-0003-0995-9771
University of Michigan · USNational Heart Lung and Blood Institute · USShanghai Jiao Tong University · CN

Funding

Purinergic modulation of the autoimmune vascular phenotypeR01HL134846 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jason Knight · 2018 to 2026
$4.8M
Mechanisms in Blood ClottingR35HL135823 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORRISSEY, JAMES H. · 2017 to 2023
$4.8M
Purinergic regulation of Innate Immunity to promote Venous HomeostasisR01HL150392 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PINSKY, DAVID J. · 2020 to 2024
$2.2M
Role of carrier plasma protein corona in their vascular wall localizationR01HL115138 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ENIOLA-ADEFESO, OMOLOLA · 2012 to 2016
$1.9M
CD39 in Vein Graft ArterializationK08HL131993 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KANTHI, YOGENDRA · 2016 to 2020
$837k
NHLBI NIH HHS K08 HL131993NHLBI NIH HHS R01 HL115138NHLBI NIH HHS R01 HL134846NHLBI NIH HHS R01 HL150392NHLBI NIH HHS R35 HL135823
6 · The paper itself

Abstract

Patients with COVID-19 are at high risk for thrombotic arterial and venous occlusions. Lung histopathology often reveals fibrin-based blockages in the small blood vessels of patients who succumb to the disease. Antiphospholipid syndrome is an acquired and potentially life-threatening thrombophilia in which patients develop pathogenic autoantibodies targeting phospholipids and phospholipid-binding proteins (aPL antibodies). Case series have recently detected aPL antibodies in patients with COVID-19. Here, we measured eight types of aPL antibodies in serum samples from 172 patients hospitalized with COVID-19. These aPL antibodies included anticardiolipin IgG, IgM, and IgA; anti-β

Indexed as

AdultAgedAged, 80 and overAnimalsAntibodies, AntiphospholipidAntiphospholipid SyndromeCohort StudiesCOVID-19Cross-Sectional StudiesDisease Models, AnimalExtracellular TrapsFemaleHumansImmunoglobulin GMaleMiceAntibodies, AntiphospholipidImmunoglobulin G

Identifiers

PMID33139519
PMCPMC7724273
OpenAlexW3094906854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.