Evidence map›Paper›PMID 33139494›Full record

ArticleMolecular and cellular biology2020

Analysis of 1,25-Dihydroxyvitamin D

Shanshan Li, Jessica De La Cruz, Steven Hutchens, Somshuvra Mukhopadhyay, Zachary K Criss, Rohit Aita, Oscar Pellon-Cardenas, Joseph Hur, Patricia Soteropoulos, Seema Husain and 7 more

Open access · greenAbstract read
In one paragraph

Article in Molecular and cellular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Overlaps in mammalian iron and manganese homeostasis: recent advances.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
  3. Article
  4. Article
  5. How Does Plasma Therapy Approach Affect VDR Expression in the Elderly?Journal of clinical practice and research · 2025
    Article
  6. Article
  7. A comprehensive transcriptome characterization of individual nuclear receptor pathways in the human small intestine.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Vitamin D and Gut Health.Advances in experimental medicine and biology · 2022
    Article
  15. Role of excretion in manganese homeostasis and neurotoxicity: a historical perspective.American journal of physiology. Gastrointestinal and liver physiology · 2022
    Review
  16. Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Shanshan LiDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey, USA.
Jessica De La CruzDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey, USA.
Steven HutchensDivision of Pharmacology and Toxicology, College of Pharmacy, Institute for Cellular and Molecular Biology and Institute for Neuroscience, The University of Texas at Austin, Austin, Texas, USA.
Somshuvra MukhopadhyayDivision of Pharmacology and Toxicology, College of Pharmacy, Institute for Cellular and Molecular Biology and Institute for Neuroscience, The University of Texas at Austin, Austin, Texas, USA.
Zachary K CrissIntegrative Molecular and Biomedical Sciences Graduate Program, Division of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Rohit AitaDepartment of Genetics, Rutgers University, New Brunswick, New Jersey, USA.
Oscar Pellon-CardenasDepartment of Genetics, Rutgers University, New Brunswick, New Jersey, USA.
Joseph HurDepartment of Genetics, Rutgers University, New Brunswick, New Jersey, USA.
Patricia SoteropoulosDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey, USA.
Seema HusainDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey, USA.
Puneet DhawanDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey, USA.
Lieve VerlindenLaboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, Leuven, Belgium.
Geert CarmelietLaboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, Leuven, Belgium.
James C FleetDepartment of Nutrition Science, Purdue University, West Lafayette, Indiana, USA.
Noah F ShroyerIntegrative Molecular and Biomedical Sciences Graduate Program, Division of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Michael P VerziDepartment of Genetics, Rutgers University, New Brunswick, New Jersey, USA.
Sylvia ChristakosDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey, USA christak@njms.rutgers.edu.ORCID 0000-0001-9148-5549
Rutgers, The State University of New Jersey · USBaylor College of Medicine · USKU Leuven · BEThe University of Texas at Austin · USPurdue University West Lafayette · US

Funding

Regulation of manganese homeostasis and detoxification by SLC30A10R01ES024812 · NIEHS · UNIVERSITY OF TEXAS AT AUSTIN · PI Somshuvra Mukhopadhyay · 2016 to 2026
$5.7M
Nutrigenomics of Intestinal Vitamin D ActionR01DK112365 · NIDDK · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI SYLVIA S CHRISTAKOS, James C. Fleet · 2017 to 2026
$4.2M
NIDDK NIH HHS R01 DK112365NIEHS NIH HHS R01 ES024812
6 · The paper itself

Abstract

Although vitamin D is critical for the function of the intestine, most studies have focused on the duodenum. We show that transgenic expression of the vitamin D receptor (VDR) only in the distal intestine of VDR null mice (KO/TG mice) results in the normalization of serum calcium and rescue of rickets. Although it had been suggested that calcium transport in the distal intestine involves a paracellular process, we found that the 1,25-dihydroxyvitamin D

Indexed as

AnimalsCalcitriolCalciumGenomicsHumansIntestinal MucosaIntestinesMiceMice, Inbred C57BLMice, TransgenicPlasma Membrane Calcium-Transporting ATPasesReceptors, CalcitriolVitamin DCalcitriolCalciumdihydroxy-vitamin D3Plasma Membrane Calcium-Transporting ATPasesReceptors, CalcitriolVitamin Dcalciumhuman enteroidsintestinemanganesemouseSlc30a10transportersTRPV6vitamin D

Identifiers

PMID33139494
PMCPMC7849401
OpenAlexW3096813908

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.