Evidence map›Paper›PMID 33139383›Full record

ArticleInfection and immunity2021

(p)ppGpp-Dependent Regulation of the Nucleotide Hydrolase PpnN Confers Complement Resistance in Salmonella enterica Serovar Typhimurium.

N Y Elizabeth Chau, Deyanira Pérez-Morales, Wael Elhenawy, Víctor H Bustamante, Yong E Zhang, Brian K Coombes

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

N Y Elizabeth ChauDepartment of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Deyanira Pérez-MoralesDepartamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, México.
Wael ElhenawyDepartment of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Víctor H BustamanteDepartamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, México.
Yong E ZhangDepartment of Biology, University of Copenhagen, Copenhagen, Denmark.
Brian K CoombesDepartment of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada coombes@mcmaster.ca.ORCID 0000-0001-9883-1010
McMaster University · CAUniversidad Nacional Autónoma de México · MXUniversity of Copenhagen · DK

Funding

CIHR FRN 156361
6 · The paper itself

Abstract

The stringent response is an essential mechanism of metabolic reprogramming during environmental stress that is mediated by the nucleotide alarmones guanosine tetraphosphate and pentaphosphate [(p)ppGpp]. In addition to physiological adaptations, (p)ppGpp also regulates virulence programs in pathogenic bacteria, including

Indexed as

Disease ResistanceGene Expression Regulation, BacterialGenetic VariationHumansImmunity, InnateLigasesN-Glycosyl HydrolasesSalmonella typhimuriumSerogroupVirulenceLigasesN-Glycosyl Hydrolasescomplementinnate immunitySalmonellaserumvirulence

Identifiers

PMID33139383
PMCPMC7822145
OpenAlexW3095514887

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.