Evidence map›Paper›PMID 33139322›Full record

ArticleeNeuro

ADAP1/Centaurin-α1 Negatively Regulates Dendritic Spine Function and Memory Formation in the Hippocampus.

Erzsebet M Szatmari, Corey Moran, Sarah Cohen, Amanda Jacob, Paula Parra-Bueno, Naomi Kamasawa, Debbie Guerrero-Given, Michael Klein, Robert Stackman, Ryohei Yasuda

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Loss of ADAP1/CentA1 Protects Against Autoimmune Demyelination.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  4. Establishment and characterization of adap1-deficient zebrafish.Development, growth & differentiation · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Erzsebet M SzatmariMax Planck Florida Institute for Neuroscience, Jupiter, FL 33458 ryohei.yasuda@mpfi.org szatmarie18@ecu.edu.
Corey MoranMax Planck Florida Institute for Neuroscience, Jupiter, FL 33458.
Sarah CohenFlorida Atlantic University, Jupiter, FL 33458.
Amanda JacobMax Planck Florida Institute for Neuroscience, Jupiter, FL 33458.
Paula Parra-BuenoMax Planck Florida Institute for Neuroscience, Jupiter, FL 33458.
Naomi KamasawaMax Planck Florida Institute for Neuroscience, Jupiter, FL 33458.ORCID 0000-0002-8926-5309
Debbie Guerrero-GivenMax Planck Florida Institute for Neuroscience, Jupiter, FL 33458.
Michael KleinMax Planck Florida Institute for Neuroscience, Jupiter, FL 33458.
Robert StackmanFlorida Atlantic University, Jupiter, FL 33458.
Ryohei YasudaMax Planck Florida Institute for Neuroscience, Jupiter, FL 33458 ryohei.yasuda@mpfi.org szatmarie18@ecu.edu.ORCID 0000-0001-6263-9297
Max Planck Florida Institute for Neuroscience · USFlorida Atlantic University · USEast Carolina University · US

Funding

Mechanisms of Ras Signaling in Single SynapsesR01MH080047 · NIMH · MAX PLANCK FLORIDA CORPORATION · PI YASUDA, RYOHEI · 2007 to 2023
$6.8M
Deciphering Biochemical Networks in Single Dendritic SpinesDP1NS096787 · NINDS · MAX PLANCK FLORIDA CORPORATION · PI YASUDA, RYOHEI · 2015 to 2019
$4.8M
NIMH NIH HHS R01 MH080047NINDS NIH HHS DP1 NS096787
6 · The paper itself

Abstract

ADAP1/Centaurin-α1 (CentA1) functions as an Arf6 GTPase-activating protein highly enriched in the brain. Previous studies demonstrated the involvement of CentA1 in brain function as a regulator of dendritic differentiation and a potential mediator of Alzheimer's disease (AD) pathogenesis. To better understand the neurobiological functions of CentA1 signaling in the brain, we developed

Indexed as

Dendritic SpinesHippocampusMemoryAdaptor Proteins, Signal TransducingAlzheimer DiseaseAnimalsGTPase-Activating ProteinsMiceNerve Tissue ProteinsAdaptor Proteins, Signal TransducingGTPase-Activating ProteinsNerve Tissue ProteinsADAP1/Centaurin-α1Arf6dendritic spineshippocampuslearning and memory

Identifiers

PMID33139322
PMCPMC7808333
OpenAlexW3097328946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.