ArticleeNeuro
The Interpeduncular-Ventral Hippocampus Pathway Mediates Active Stress Coping and Natural Reward.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Protocol for monitoring neurotransmitter release upon projection-specific activation in mouse dorsal raphe nucleus via in vivo fiber photometry.STAR protocols · 2026Article
- Brain-Wide Patterns of CRF Receptor 1 Expression in the Transgenic CRFR1-Cre-2a-tdTom Rat.The Journal of comparative neurology · 2025Article
- Nicotine and neuronal nicotinic acetylcholine receptors: unraveling the mechanisms of nicotine addiction.Frontiers in neuroscience · 2025Review
- Intranasal delivery of shRNA to knockdown the 5HT-2A receptor enhances memory and alleviates anxiety.Translational psychiatry · 2024Article
- The effect of reward on motor learning: different stage, different effect.Frontiers in human neuroscience · 2024Review
- Genetic modulation of thePNAS nexus · 2023Article
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- Selective Menin Deletion in the Hippocampal CA1 Region Leads to Disruption of Contextual Memory in theCells · 2022Article
- The complexity of ventral CA1 and its multiple functionalities.Genes, brain, and behavior · 2022Review
- Neurobiological Mechanisms of Nicotine Reward and Aversion.Pharmacological reviews · 2022Review
- Stress Adaptation and the Brainstem with Focus on Corticotropin-Releasing Hormone.International journal of molecular sciences · 2021Review
- Addiction-related neuroadaptations following chronic nicotine exposure.Journal of neurochemistry · 2021Review
- Multidimensional Intersection of Nicotine, Gene Expression, and Behavior.Frontiers in behavioral neuroscience · 2021Article
- Differential Expression Patterns of Lynx Proteins and Involvement of Lynx1 in Prepulse Inhibition.Frontiers in behavioral neuroscience · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Maladaptive stress-related behaviors are integral to multiple complex psychiatric disorders, and it has been well established that serotonergic signaling mediates various aspects of these maladaptive states. In these studies, we sought to uncover the function of a previously undefined serotonergic pathway, which projects from the interpeduncular nucleus (IPN) to the ventral hippocampus (vHipp). Intersectional retrograde and chemogenetic viral manipulation strategies were employed to manipulate the function of the IPN-vHipp pathway during a variety of behavioral measures in male mice. We found a significant effect of circuit inhibition on behaviors associated with coping strategies and natural reward. Specifically, inhibition of the IPN-vHipp pathway dramatically increased active stress-induced escape behaviors, in addition to moderately affecting sucrose consumption and food self-administration. During inhibition of this pathway, agonist activation of serotonergic 5-HT
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.