Evidence map›Paper›PMID 33139288›Full record

ArticleAntimicrobial agents and chemotherapy2021

Atypical Mutation in Neisseria gonorrhoeae 23S rRNA Associated with High-Level Azithromycin Resistance.

Cau D Pham, Evelyn Nash, Hsi Liu, Matthew W Schmerer, Samera Sharpe, Grace Woods, Brad Roland, Karen Schlanger, Sancta B St Cyr, Jonathan Carlson and 7 more

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Heterogeneity of azithromycin resistance markers inNew microbes and new infections · 2026
    Review
  2. Article
  3. Evaluation of the Allplex NG & DR assay for molecular prediction of ciprofloxacin and azithromycin resistance in Neisseria gonorrhoeae.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  4. Article
  5. Local emergence and global evolution ofAntimicrobial agents and chemotherapy · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Horizontal Gene Transfer and Drug Resistance InvolvingAntibiotics (Basel, Switzerland) · 2023
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 1 country.

Cau D PhamCenters for Disease Control and Prevention, Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB, Atlanta, Georgia, USA whi4@cdc.gov.ORCID 0000-0002-9569-2147
Evelyn NashCenters for Disease Control and Prevention, Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB, Atlanta, Georgia, USA.
Hsi LiuCenters for Disease Control and Prevention, Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB, Atlanta, Georgia, USA.ORCID 0000-0002-4270-3017
Matthew W SchmererCenters for Disease Control and Prevention, Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB, Atlanta, Georgia, USA.ORCID 0000-0002-6756-1756
Samera SharpeCenters for Disease Control and Prevention, Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB, Atlanta, Georgia, USA.
Grace WoodsCenters for Disease Control and Prevention, Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB, Atlanta, Georgia, USA.
Brad RolandCenters for Disease Control and Prevention, Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB, Atlanta, Georgia, USA.
Karen SchlangerCenters for Disease Control and Prevention, Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB, Atlanta, Georgia, USA.
Sancta B St CyrCenters for Disease Control and Prevention, Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB, Atlanta, Georgia, USA.
Jonathan CarlsonSan Francisco Department of Public Health, San Francisco, California, USA.
Kevin SellersSan Francisco Department of Public Health, San Francisco, California, USA.
Aaron OlsenNew York City Department of Health and Mental Hygiene, New York, New York, USA.
Ruth SanonFlorida Department of Health, Tallahassee, Florida, USA.
Henrietta HardinTennessee Department of Health, Knoxville, Tennessee, USA.
Olusegun O SogeUniversity of Washington, Seattle, Washington, USA.
Brian H RaphaelCenters for Disease Control and Prevention, Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB, Atlanta, Georgia, USA.
Ellen N KershCenters for Disease Control and Prevention, Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB, Atlanta, Georgia, USA.ORCID 0000-0003-3819-0324
Centers for Disease Control and Prevention · USSan Francisco Department of Public Health · USFlorida Department of Health · USNew York City Department of Health and Mental Hygiene · USTennessee Department of Health · USUniversity of Washington · US

Funding

CDC HHS
6 · The paper itself

Abstract

A2059G mutation in the 23S rRNA gene is the only reported mechanism conferring high-level azithromycin resistance (HL-AZMR) in

Indexed as

AzithromycinGonorrheaAnti-Bacterial AgentsDrug Resistance, BacterialHumansMicrobial Sensitivity TestsMutationNeisseria gonorrhoeaeRNA, Ribosomal, 23SAnti-Bacterial AgentsAzithromycinRNA, Ribosomal, 23S23s rRNAA2058Gantibiotic resistanceazithromycin resistantgonorrheaHL-AZMRNeisseria gonorrhoeae

Identifiers

PMID33139288
PMCPMC7848993
OpenAlexW3096962849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.