Evidence map›Paper›PMID 33139287›Full record

ArticleAntimicrobial agents and chemotherapy2021

Structural and Cellular Insights into the l,d-Transpeptidase YcbB as a Therapeutic Target in Citrobacter rodentium,

N A Caveney, A Serapio-Palacios, S E Woodward, T Bozorgmehr, G Caballero, M Vuckovic, W Deng, B B Finlay, N C J Strynadka

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Peptidoglycan LD-Transpeptidases.Antibiotics (Basel, Switzerland) · 2025
    Review
  2. Article
  3. Article
  4. The l,d-Transpeptidase LdtACS infectious diseases · 2022
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

N A CaveneyDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0003-4828-3479
A Serapio-PalaciosMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0001-8199-0189
S E WoodwardMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
T BozorgmehrMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
G CaballeroDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
M VuckovicDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
W DengMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
B B FinlayDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada bfinlay@msl.ubc.ca ncjs@mail.ubc.ca.ORCID 0000-0001-5303-6128
N C J StrynadkaDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada bfinlay@msl.ubc.ca ncjs@mail.ubc.ca.ORCID 0000-0002-4058-9425
University of British Columbia · CA

Funding

CIHR
6 · The paper itself

Abstract

The bacterial cell wall plays a key role in viability and is an important drug target. The cell wall is made of elongated polymers that are cross-linked to one another to form a load-bearing mesh. An alternative cell wall cross-linking mechanism used by the l,d-transpeptidase YcbB has been implicated in the stress-regulated roles of β-lactam resistance, outer membrane defect rescue, and typhoid toxin release. The role for this stress-linked cross-linking in the context of a host infection was unclear. Here, we resolve the crystallographic structures of both

Indexed as

Peptidyl TransferasesTyphoid FeverAnimalsCitrobacter rodentiumMiceSalmonella typhiSalmonella typhimuriumPeptidyl Transferasesbacterial infectioncarbapeneml,d-transpeptidasestructural biology

Identifiers

PMID33139287
PMCPMC7849009
OpenAlexW3097869998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.