Evidence map›Paper›PMID 33139286›Full record

ArticleAntimicrobial agents and chemotherapy2020

Effect of a Neuropilin-1-Derived Virus Receptor Trap on Enterovirus A71 Infection

Hsiang-Ching Wang, Peng-Nien Huang, Hui-Chen Hung, Sung-Nien Tseng, Chia-Chia Chang, Ya-Ru Tsai, Yun-Ming Wang, Shin-Ru Shih, John Tsu-An Hsu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Neuropilin (NRPs) Related Pathological Conditions and Their Modulators.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Hsiang-Ching Wang *Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.
Peng-Nien Huang *Research Center for Emerging Viral Infections, Chang Gung University, Taoyuan, Taiwan.
Hui-Chen Hung *Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan.
Sung-Nien TsengResearch Center for Emerging Viral Infections, Chang Gung University, Taoyuan, Taiwan.
Chia-Chia ChangAnimal Drugs Inspection Branch, Animal Health Research Institute, Council of Agriculture, Miaoli County, Taiwan.
Ya-Ru TsaiInstitute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan.
Yun-Ming WangDepartment of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, Center For Intelligent Drug Systems and Smart Bio-devices (IDS2B), National Chiao Tung University, Hsinchu, Taiwan.
Shin-Ru ShihResearch Center for Emerging Viral Infections, Chang Gung University, Taoyuan, Taiwan.ORCID 0000-0003-4874-401X
John Tsu-An HsuDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan tsuanhsu@nhri.edu.tw.ORCID 0000-0002-8766-8681
Chang Gung University · TWNational Yang Ming Chiao Tung University · TWNational Health Research Institutes · TWCouncil of Agriculture · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We discovered that neuropilin 1 (NRP1) is a new receptor candidate to mediate enterovirus A71 (EVA71) into cells. In the engineered form as a decoy receptor, NRP1 was able to recognize and neutralize EVA71 but not enterovirus D68 or coxsackievirus B3 (CVB3). NRP1 recognizes EVA71 through a novel domain on the VP3 capsid protein. The principle in the design, engineering, and refinement of the NRP1-based decoy receptor described in this study represents a general and well-suited antiviral strategy.

Indexed as

EnterovirusEnterovirus A, HumanEnterovirus InfectionsHumansNeuropilin-1Receptors, VirusNeuropilin-1Receptors, Virusantiviral researchdecoy receptorenterovirus A71neuropilin 1virus receptor trap

Identifiers

PMID33139286
PMCPMC7927848
OpenAlexW3097340717

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.