Evidence map›Paper›PMID 33139065›Full record

ArticleSurgery2021

Current state of intraoperative use of near infrared fluorescence for parathyroid identification and preservation.

Carmen C Solórzano, Giju Thomas, Eren Berber, Tracy S Wang, Gregory W Randolph, Quan-Yang Duh, Frédéric Triponez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carmen C SolórzanoDivision of Surgical Oncology and Endocrine Surgery, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN. Electronic address: carmen.solorzano@vumc.org.
Giju ThomasVanderbilt Biophotonics Center, Department of Biomedical Engineering, Vanderbilt University, Nashville, TN.
Eren BerberDepartment of Endocrine Surgery, Cleveland Clinic, Cleveland, OH.
Tracy S WangSection of Endocrine Surgery, Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI.
Gregory W RandolphMassachusetts Eye and Ear Infirmary, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Quan-Yang DuhSection of Endocrine Surgery, Department of Surgery, University of California, San Francisco, CA.
Frédéric TriponezDepartment of Thoracic and Endocrine Surgery, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Funding

Academic-Industry Partnership for the Translation of a Novel Optical Imaging Approach to guide Endocrine Cancer SurgeryR01CA212147 · NCI · VANDERBILT UNIVERSITY · PI MAHADEVAN-JANSEN, ANITA · 2018 to 2022
$2.7M
NCI NIH HHS R01 CA212147
6 · The paper itself

Abstract

backgroundFinding and preserving normal parathyroid glands or localizing and removing diseased parathyroid glands are crucial steps to successful thyroid and parathyroid operations. Using near-infrared fluorescence detection to identify parathyroid glands during thyroid and parathyroid operations has lately gained widespread recognition, with 2 Food and Drug Administration-cleared devices currently in the market. We aim to update the endocrine surgery community on how near-infrared fluorescence detection can be most optimally used for rapid intraoperative parathyroid gland identification or preservation.

methodsA literature review was performed using the key terms: "parathyroid," "near infrared," and "fluorescence" in relevant search engines. Based on the reviewed literature and expert surgeons' opinions, recommendations were formulated for applying near-infrared fluorescence detection to identify or preserve parathyroid glands during cervical endocrine surgery.

resultsThe scope of near-infrared fluorescence detection can be broadly categorized into (1) using near-infrared auto-fluorescence to identify or locate both healthy and diseased parathyroid glands, and (2) using contrast-enhanced near-infrared fluorescence to evaluate parathyroid gland perfusion. The benefits and pitfalls for both near-infrared-based approaches are described herein.

conclusionNear-infrared fluorescence detection appears helpful for identification and likely preservation of parathyroid glands. We hope these recommendations will be valuable to the practicing endocrine surgeon as they consider incorporating these intraoperative adjuncts in their surgical practice.

Indexed as

Intraoperative CareOrgan PreservationSpectrometry, FluorescenceSpectroscopy, Near-InfraredClinical Decision-MakingContrast MediaDisease ManagementHumansMolecular ProbesParathyroidectomyParathyroid GlandsPerfusionReproducibility of ResultsThyroidectomyThyroid GlandContrast MediaMolecular Probes

Identifiers

PMID33139065
PMCPMC7987670

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.