Evidence map›Paper›PMID 33138936›Full record

ArticleJournal of the American Medical Directors Association2020

Predictors of In-Hospital Mortality in Older Patients With COVID-19: The COVIDAge Study.

Aline Mendes, Christine Serratrice, François R Herrmann, Laurence Genton, Samuel Périvier, Max Scheffler, Thomas Fassier, Philippe Huber, Marie-Claire Jacques, Virginie Prendki and 7 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Medical Directors Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04756479 (Predictors of Intrahospital Mortality in Older Patients Admitted Due to COVID-19 in the COVID-19 AGEBRU Study), which is not on this map. Cited by 69 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04756479 completednot on this map

Predictors of Intrahospital Mortality in Older Patients Admitted Due to COVID-19 in the COVID-19 AGEBRU Study

TypeobservationalSponsorBrugmann University HospitalRan2020 to 2020Enrolled160ConditionsCovid19, Old Age, Debility, Morbidity, Multiple
3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pre-existing atrial fibrillation is associated with increased mortality in COVID-19 Patients.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2021
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Aline MendesDivision of Geriatrics, University Hospitals of Geneva, Geneva, Switzerland. Electronic address: aline.mendes@hcuge.ch.
Christine SerratriceDivison of Internal Medicine for the aged, University Hospitals of Geneva, Geneva, Switzerland.
François R HerrmannDivision of Geriatrics, University Hospitals of Geneva, Geneva, Switzerland.
Laurence GentonClinical Nutrition, University Hospitals of Geneva, Geneva, Switzerland.
Samuel PérivierDivision of Geriatrics, University Hospitals of Geneva, Geneva, Switzerland.
Max SchefflerDivision of Radiology, University Hospitals of Geneva, Geneva, Switzerland.
Thomas FassierDivison of Internal Medicine for the aged, University Hospitals of Geneva, Geneva, Switzerland.
Philippe HuberDivision of Geriatrics, University Hospitals of Geneva, Geneva, Switzerland.
Marie-Claire JacquesDivision of Geriatrics, University Hospitals of Geneva, Geneva, Switzerland.
Virginie PrendkiDivison of Internal Medicine for the aged, University Hospitals of Geneva, Geneva, Switzerland.
Xavier RouxDivison of Internal Medicine for the aged, University Hospitals of Geneva, Geneva, Switzerland.
Katharine Di SilvestroDivison of Internal Medicine for the aged, University Hospitals of Geneva, Geneva, Switzerland.
Véronique TrombertDivison of Internal Medicine for the aged, University Hospitals of Geneva, Geneva, Switzerland.
Stephan HarbarthDivision of Infectious Diseases and Infection Control Program, University Hospitals of Geneva and Faculty of Medicine, Geneva, Switzerland.
Gabriel GoldDivision of Geriatrics, University Hospitals of Geneva, Geneva, Switzerland.
Christophe E GrafDivision of Internal Medicine and Rehabilitation, University Hospitals of Geneva, Geneva, Switzerland.
Dina ZekryDivison of Internal Medicine for the aged, University Hospitals of Geneva, Geneva, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine predictors of in-hospital mortality related to COVID-19 in older patients.

designRetrospective cohort study. SETTING AND

participantsPatients aged 65 years and older hospitalized for a diagnosis of COVID-19.

methodsData from hospital admission were collected from the electronic medical records. Logistic regression and Cox proportional hazard models were used to predict mortality, our primary outcome. Variables at hospital admission were categorized according to the following domains: demographics, clinical history, comorbidities, previous treatment, clinical status, vital signs, clinical scales and scores, routine laboratory analysis, and imaging results.

resultsOf a total of 235 Caucasian patients, 43% were male, with a mean age of 86 ± 6.5 years. Seventy-six patients (32%) died. Nonsurvivors had a shorter number of days from initial symptoms to hospitalization (P = .007) and the length of stay in acute wards than survivors (P < .001). Similarly, they had a higher prevalence of heart failure (P = .044), peripheral artery disease (P = .009), crackles at clinical status (P < .001), respiratory rate (P = .005), oxygen support needs (P < .001), C-reactive protein (P < .001), bilateral and peripheral infiltrates on chest radiographs (P = .001), and a lower prevalence of headache (P = .009). Furthermore, nonsurvivors were more often frail (P < .001), with worse functional status (P < .001), higher comorbidity burden (P < .001), and delirium at admission (P = .007). A multivariable Cox model showed that male sex (HR 4.00, 95% CI 2.08-7.71, P < .001), increased fraction of inspired oxygen (HR 1.06, 95% CI 1.03-1.09, P < .001), and crackles (HR 2.42, 95% CI 1.15-6.06, P = .019) were the best predictors of mortality, while better functional status was protective (HR 0.98, 95% CI 0.97-0.99, P = .001). CONCLUSIONS AND IMPLICATIONS: In older patients hospitalized for COVID-19, male sex, crackles, a higher fraction of inspired oxygen, and functionality were independent risk factors of mortality. These routine parameters, and not differences in age, should be used to evaluate prognosis in older patients.

Indexed as

AgedAged, 80 and overBetacoronavirusComorbidityCoronavirus InfectionsCOVID-19FemaleForecastingGeriatricsHospital MortalityHumansMalePandemicsPneumonia, ViralPrognosisProportional Hazards ModelsCOVID-19Mortalityolder patients

Identifiers

PMID33138936
PMCPMC7491997

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.