Evidence map›Paper›PMID 33138916›Full record

ArticleeLife2020

Direct glia-to-neuron transdifferentiation gives rise to a pair of male-specific neurons that ensure nimble male mating.

Laura Molina-García, Carla Lloret-Fernández, Steven J Cook, Byunghyuk Kim, Rachel C Bonnington, Michele Sammut, Jack M O'Shea, Sophie Pr Gilbert, David J Elliott, David H Hall and 3 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
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  5. Quantification ofmicroPublication biology · 2026
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  9. Article
  10. Review
  11. Review
  12. Journal of biosciences · 2025
    Review
  13. Glia Development and Function in the NematodeCold Spring Harbor perspectives in biology · 2024
    Review
  14. Morphologically defined substages of tail morphogenesis in C. elegans males.Developmental dynamics : an official publication of the American Association of Anatomists · 2024
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Morphologically defined substages of tail morphogenesis inbioRxiv : the preprint server for biology · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Laura Molina-García *Department of Cell and Developmental Biology, University College London, London, United Kingdom.ORCID 0000-0002-1530-4061
Carla Lloret-Fernández *Department of Cell and Developmental Biology, University College London, London, United Kingdom.ORCID 0000-0002-5370-9318
Steven J CookDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, United States.ORCID 0000-0002-1345-7566
Byunghyuk KimDepartment of Genetics, Albert Einstein College of Medicine, New York, United States.ORCID 0000-0002-2220-4173
Rachel C BonningtonDepartment of Cell and Developmental Biology, University College London, London, United Kingdom.ORCID 0000-0002-5652-0297
Michele SammutDepartment of Cell and Developmental Biology, University College London, London, United Kingdom.ORCID 0000-0002-0281-6121
Jack M O'SheaDepartment of Cell and Developmental Biology, University College London, London, United Kingdom.ORCID 0000-0002-9694-7340
Sophie Pr GilbertDepartment of Cell and Developmental Biology, University College London, London, United Kingdom.
David J ElliottDepartment of Cell and Developmental Biology, University College London, London, United Kingdom.
David H HallDepartment of Genetics, Albert Einstein College of Medicine, New York, United States.ORCID 0000-0001-8459-9820
Scott W EmmonsDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, United States.ORCID 0000-0002-6511-9972
Arantza BarriosDepartment of Cell and Developmental Biology, University College London, London, United Kingdom.ORCID 0000-0001-6153-8830
Richard J PooleDepartment of Cell and Developmental Biology, University College London, London, United Kingdom.ORCID 0000-0001-6414-2479
University College London · GBAlbert Einstein College of Medicine · US

Funding

TRAINING PROGRAM IN CELLULAR &MOLEC. BIOLOGY &GENETICST32GM007491 · NIGMS · YESHIVA UNIVERSITY · PI QUERY, CHARLES C · 1985 to 2021
$17.0M
Center for C elegans AnatomyR24OD010943 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DAVID H. HALL, Nathan Schroeder · 2012 to 2026
$9.6M
CENTER FOR CAENORHABDITIS ELGANS ANATOMYR24RR012596 · NCRR · YESHIVA UNIVERSITY · PI HALL, DAVID H. · 1998 to 2011
$8.0M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Genetic Analysis of Nematode BehaviorR01GM066897 · NIGMS · YESHIVA UNIVERSITY · PI EMMONS, SCOTT W · 2003 to 2013
$2.2M
Genetic analyses of complete circuit formation in Caenorhabditis elegansF32MH115438 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI COOK, STEVEN JAY · 2017 to 2021
$226k
NCRR NIH HHS R24 RR012596NIGMS NIH HHS R01 GM066897NIGMS NIH HHS T32 GM007491NIH HHS F32 MH115438NIH HHS OD 010943NIH HHS P40 OD010440NIH HHS R01 GM066897NIH HHS R24 OD010943NIH HHS T32 GM007491NIMH NIH HHS F32 MH115438Wellcome TrustWellcome Trust Enhancement Funding 095722/Z/11/AWellcome Trust PhD StudentshipWellcome Trust Research Career Development Fellowship 095722/Z/11/ZWellcome Trust Senior Research Fellowship 207483/Z/17/Z
6 · The paper itself

Abstract

Sexually dimorphic behaviours require underlying differences in the nervous system between males and females. The extent to which nervous systems are sexually dimorphic and the cellular and molecular mechanisms that regulate these differences are only beginning to be understood. We reveal here a novel mechanism by which male-specific neurons are generated in

Indexed as

Cell TransdifferentiationSexual Behavior, AnimalAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsCalciumCell CommunicationCell LineageCopulationFemaleMaleNeurogliaNeuronsReproductionRNA InterferenceCaenorhabditis elegans ProteinsCalciumC. elegansdevelopmental biologyglianeuroscienceproprioceptionreproductive behavioursexual dimorphismtransdifferentiation

Identifiers

PMID33138916
PMCPMC7609048
OpenAlexW3094878316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.