ArticleBMC veterinary research2020
Successful management of portal vein thrombosis in a Yorkshire Terrier with protein-losing enteropathy.
Article in BMC veterinary research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Efficacy of dual therapy with rivaroxaban and clopidogrel in canine aortic thrombosis resistant to clopidogrel monotherapy: two case reports.The Journal of veterinary medical science · 2026Article
- Treatment of portal vein thrombosis with rivaroxaban in an American cocker spaniel with chronic hepatitis: a case report.The Journal of veterinary medical science · 2025Article
- Coagulation Status Assessment in Dogs with Chronic Enteropathy Using Viscoelastic Point-of-Care Coagulation Monitor.Animals : an open access journal from MDPI · 2025Article
- Analysis of Complications and Risk Factors Other than Bleeding before and after Endoscopic Treatment of Esophagogastric Variceal Bleeding in Patients with Liver Cirrhosis.Canadian journal of gastroenterology & hepatology · 2023Article
- 2022 Update of the Consensus on the Rational Use of Antithrombotics and Thrombolytics in Veterinary Critical Care (CURATIVE) Domain 1- Defining populations at risk.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) · 2022Article
- Long-term follow-up of portal vein thrombosis in an American Cocker Spaniel with lobular dissecting hepatitis: a case report.BMC veterinary research · 2021Article
- Monitoring of Rivaroxaban Therapy in Hypercoagulable Dogs.Journal of veterinary internal medicineArticle
- Comparison of the pharmacokinetics and pharmacodynamics of apixaban and rivaroxaban in dogs.Journal of veterinary internal medicineArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPortal vein thrombosis (PVT) is a rare presentation in dogs with protein-losing enteropathy (PLE). Rivaroxaban, an oral, selective, direct factor Xa inhibitor, has not been reported to be administrated for canine PVT and the effect is unclear in dogs with PLE. CASE PRESENTATION: An 11-year-old Yorkshire Terrier presented with moderate ascites. The dog had severe hypoalbuminemia (1.2 g/dL), and a portal vein thrombus was confirmed on computed tomographic angiography (CTA). On endoscopic examination, it became apparent that the hypoalbuminemia was caused by PLE, which was consequent of lymphatic dilation and lymphoplasmacytic enteritis. Therefore, the dog was initially treated with oral administrations of spironolactone and clopidogrel, with dietary fat restriction. However, a follow-up CTA showed no changes in the ascites, thrombus, and portal vein to aorta (PV/Ao) ratio. Therefore, the dog was additionally prescribed rivaroxaban and low-dose prednisolone for the portal vein thrombus and hypoalbuminemia due to lymphoplasmacytic enteritis, respectively. Following the treatment, the PV/Ao ratio decreased because of a decrease in the thrombus and the ascites disappeared completely with an elevation of albumin concentration (1.9 g/dL).
conclusionsThis case report demonstrated that oral administration of rivaroxaban combined with low-dose glucocorticoid was effective management for PVT in a dog with PLE.
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