ArticleBMC psychiatry2020
Urinary incontinence associated with anxiety and depression: the impact of psychotropic drugs in a cross-sectional study from the Norwegian HUNT study.
Article in BMC psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Prevalence and determinants of depression among women with urinary incontinence: a systematic review and meta-analysis worldwide.BMC women's health · 2024Pooled it
- The impact of urinary incontinence on multiple health outcomes: an umbrella review of meta-analysis of observational studies.Aging clinical and experimental research · 2023Pooled it
- Effect of single doses of citalopram and reboxetine on urethral pressure: A randomized, double-blind, placebo- and active-controlled three-period crossover study in healthy women.Neurourology and urodynamics · 2022Trial
- Exploring the Association Between Urinary Incontinence and Depression Based on a Series of Large-Scale National Health Studies in Türkiye.Journal of clinical medicine · 2025Article
- Bidirectional relationships between depression, anxiety and urinary symptoms in women: A prospective cohort study.Journal of affective disorders · 2025Article
- Associations Between the Number of Vaginal Delivery and Urinary Incontinence in Women Before and After Natural Menopause: A Cross-Sectional Study.International journal of women's health · 2025Article
- Sleep Quality and Urinary Incontinence in Prostate Cancer Patients: A Data Analytics Approach with the ASCAPE Dataset.Healthcare (Basel, Switzerland) · 2024Article
- Digital Care Program for Urinary Incontinence in Females: A Large-Scale, Prospective, Cohort Study.Healthcare (Basel, Switzerland) · 2024Article
- When Bladder and Brain Collide: Is There a Gender Difference in the Relationship between Urinary Incontinence, Chronic Depression, and Anxiety?Journal of clinical medicine · 2023Article
- Association of urinary incontinence with depression among men: a cross-sectional study.BMC public health · 2023Article
- Pilates Method and/or Photobiomodulation Therapy Combined to Static Magnetic Field in Women with Stress Urinary Incontinence: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.Journal of clinical medicine · 2023Article
- Prevalence and clinical correlates for depression in women with urinary incontinence: a cross-sectional study.International urogynecology journal · 2022Article
- Multidisciplinary treatment for functional urological disorders with psychosomatic comorbidity in a tertiary pelvic care center-A retrospective cohort study.Neurourology and urodynamics · 2022Observational
- Sport-related risk factors for moderate or severe urinary incontinence in master female weightlifters: A cross-sectional study.PloS one · 2022Article
- Psychiatric History and Overactive Bladder Symptom Severity in Ambulatory Urogynecological Patients.Journal of clinical medicine · 2021Article
- Family Physician's Educational Interview with Patients Helps in Early Recognition of Lower Urinary Tract Symptoms.International journal of general medicine · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnxiety and depression are in both cross-sectional and longitudinal studies associated with urinary incontinence (UI) in women, strongest for the urgency component of UI. The role of psychotropic drugs in this association, especially antidepressants, has been questioned, but not clarified. The present study aimed to explore the associations between UI and anxiety/depression and the possible impact of psychotropic drugs on these associations.
methodsWe conducted a cross-sectional, population-based study with questionnaire data from 21,803 women ≥20 years in the Norwegian Nord-Trøndelag Health Study merged with the Norwegian Prescription Database, which contains information on all dispensed prescriptions. We used multivariate logistic regression to investigate the association between UI (any UI, and by type and severity) and anxiety/depression (by different score on Hospital anxiety and depression scale), and the influence of psychotropic drugs on this association (by different volume of drug use).
resultsCompared with normal anxiety- and depression score, having moderate/severe anxiety or depression (HADS≥11) increased the prevalence of UI from 27.6 to 37.8% (OR 1.59 (1.40-1.81), p < 0.001) for anxiety and from 28.0 to 43.7% (OR 1.79 (1.46-2.21), p < 0.001) for depression. According to type of UI, mixed UI was most strongly associated with a high HADS-score with an odds ratio 1.84 (1.65-2.05) for anxiety and 1.85 (1.61-2.13) for depression. Compared to no UI, severe UI was associated with depression with odds ratios of 2.04 (1.74-2.40), compared with no UI. Psychotropic drug use did not influence the associations between UI and anxiety/depression. We found high prevalence of UI among users of various psychotropic drugs. After adjustments, only antidepressants were associated with UI, with OR 1.36 (1.08-1.71) for high defined daily dose of the drug. Anxiolytics were associated with less UI with OR 0.64 (0.45-0.91) after adjustments for anxiety.
conclusionThis study showed that anxiety, depression and use of antidepressants are associated factors with UI, strongest for urgency and mixed type of UI, with increasing ORs by increasing severity of the conditions and increased daily dose of the medication. Use of antidepressants did not influence the associations between UI and anxiety/depression.
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