Evidence map›Paper›PMID 33138277›Full record

ArticleGenes2020

Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations.

Anca Liliana Cismaru, Deborah Rudin, Luisa Ibañez, Evangelia Liakoni, Nicolas Bonadies, Reinhold Kreutz, Alfonso Carvajal, Maria Isabel Lucena, Javier Martin, Esther Sancho Ponce and 9 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Metamizole: Indications and Risks.Deutsches Arzteblatt international · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Metamizole-induced agranulocytosis (MIA): a mini review.Molecular and cellular pediatrics · 2023
    Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 10 institutions in 5 countries.

Anca Liliana CismaruDepartment of Clinical Chemistry, Inselspital Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Deborah RudinDepartment of Clinical Pharmacology & Toxicology, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.ORCID 0000-0003-3069-9732
Luisa IbañezClinical Pharmacology Service, Hospital Universitari Vall d'Hebron, Department of Pharmacology, Therapeutics and Toxicology, Autonomous University of Barcelona, Fundació Institut Català de Farmacología, 08035 Barcelona, Spain.ORCID 0000-0002-1175-0574
Evangelia LiakoniDepartment of Clinical Pharmacology & Toxicology, Inselspital Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0002-2239-1378
Nicolas BonadiesDepartment of Hematology and Central Hematology Laboratory, Inselspital Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0001-8761-2066
Reinhold KreutzCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institut für Klinische Pharmakologie und Toxikologie, 10117 Berlin, Germany.
Alfonso CarvajalCentro de Estudios sobre la Seguridad de los Medicamentos, Universidad de Valladolid, 47005 Valladolid, Spain.
Maria Isabel LucenaServicio Farmacologia Clinica, Instituto de Investigación Biomedica de Málaga, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, 29010 Málaga, Spain.
Javier MartinInstituto de Parasitología y Biomedicina Lopez-Neyra, Consejo Superior de Investigaciones Cientiíficas, 18016 Granada, Spain.
Esther Sancho PonceServei d'Hematologia i Banc de Sang, Hospital General de Catalunya, 08190 Sant Cugat del Vallès, Spain.
Mariam MolokhiaDepartment of Population Health Sciences, King's College London, London WC2R 2LS, UK.
Niclas ErikssonUppsala Clinical Research Center and Department of Medical Sciences, Uppsala University, 751 85 Uppsala, Sweden.
EuDAC Collaborators
Stephan KrähenbühlDepartment of Clinical Pharmacology & Toxicology, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.
Carlo R LargiadèrDepartment of Clinical Chemistry, Inselspital Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Manuel HaschkeDepartment of Clinical Pharmacology & Toxicology, Inselspital Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Pär HallbergDepartment of Medical Sciences, Clinical Pharmacology and Science for Life Laboratory, Uppsala University, 751 85 Uppsala, Sweden.
Mia WadeliusDepartment of Medical Sciences, Clinical Pharmacology and Science for Life Laboratory, Uppsala University, 751 85 Uppsala, Sweden.ORCID 0000-0002-6368-2622
Ursula AmstutzDepartment of Clinical Chemistry, Inselspital Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
University of Bern · CHUniversity of Basel · CHUppsala University · SEHospital General de Catalunya · ESHumboldt-Universität zu Berlin · DEInstituto de Investigación Biomédica de Málaga · ESInstituto de Parasitología y Biomedicina "López - Neyra" · ESKing's College London · GBUniversidad de Valladolid · ESUniversitat Autònoma de Barcelona · ES

Funding

Department of Health
6 · The paper itself

Abstract

Agranulocytosis is a rare yet severe idiosyncratic adverse drug reaction to metamizole, an analgesic widely used in countries such as Switzerland and Germany. Notably, an underlying mechanism has not yet been fully elucidated and no predictive factors are known to identify at-risk patients. With the aim to identify genetic susceptibility variants to metamizole-induced agranulocytosis (MIA) and neutropenia (MIN), we conducted a retrospective multi-center collaboration including cases and controls from three European populations. Association analyses were performed using genome-wide genotyping data from a Swiss cohort (45 cases, 191 controls) followed by replication in two independent European cohorts (41 cases, 273 controls) and a joint discovery meta-analysis. No genome-wide significant associations (

Indexed as

AdultAgedAged, 80 and overAgranulocytosisBiomarkers, PharmacologicalCase-Control StudiesDipyroneEuropeFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGermanyHumansMaleMiddle AgedNeutropeniaBiomarkers, PharmacologicalDipyronedipyronedrug-induced agranulocytosisgenome-wide association studymetamizolepharmacogenetics

Identifiers

PMID33138277
PMCPMC7716224
OpenAlexW3097476737

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.