Evidence map›Paper›PMID 33138266›Full record

ArticleJournal of clinical medicine2020

Management of Medication-Related Osteonecrosis of the Jaw (MRONJ) Using Leukocyte- and Platelet-Rich Fibrin (L-PRF) and Photobiomodulation: A Retrospective Study.

Gianluca Tenore, Angela Zimbalatti, Federica Rocchetti, Francesca Graniero, Domenico Gaglioti, Ahmed Mohsen, Martina Caputo, Marco Lollobrigida, Luca Lamazza, Alberto De Biase and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 4 pooled it
3.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 70 citations in OpenAlex.

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  20. Using platelet concentrates to treat maxillofacial tissue lesions.Frontiers in bioengineering and biotechnology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Gianluca TenoreDepartment of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-9963-8052
Angela ZimbalattiDepartment of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, Italy.
Federica RocchettiDepartment of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, Italy.
Francesca GranieroDepartment of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, Italy.
Domenico GagliotiDepartment of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, Italy.
Ahmed MohsenDepartment of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-7857-4416
Martina CaputoDepartment of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, Italy.
Marco LollobrigidaDepartment of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-8182-5618
Luca LamazzaDepartment of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-4395-116X
Alberto De BiaseDepartment of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, Italy.
Ersilia BarbatoDepartment of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, Italy.
Umberto RomeoDepartment of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0003-2439-2187
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to compare retrospectively the effect of three different treatment protocols on the healing outcome in patients with established medication-related osteonecrosis of the jaw (MRONJ).

methodsA total of 34 MRONJ patients were recruited from the Department database and were divided according to the treatment protocols in a study group (G1) and two control groups (G2 and G3). G1 was treated with antibiotic therapy, surgery, leukocyte- and platelet-rich fibrin (L-PRF), and photobiomodulation; G2 was treated with antibiotic therapy and surgery; G3 was treated with antibiotic therapy and photobiomodulation. Various clinical variables and treatment protocols were analyzed to determine their correlation with the healing outcome at three and six months of follow-up.

resultsThere was a significant association between the different treatment protocols and the outcomes at both three and six months follow-up (

conclusionsOur results show that the combination of antibiotic therapy, surgery, L-PRF, and photobiomodulation may effectively contribute to MRONJ management.

Indexed as

autologous platelet concentrateslaser therapyleukocyte- and platelet-rich fibrinmedication-related osteonecrosis of the jaworal surgeryphotobiomodulation

Identifiers

PMID33138266
PMCPMC7693575
OpenAlexW3094911712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.