ReviewBiomimetics (Basel, Switzerland)2020
The Use of Simulated Body Fluid (SBF) for Assessing Materials Bioactivity in the Context of Tissue Engineering: Review and Challenges.
Review in Biomimetics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 233 citations in OpenAlex.
- Synthesis, Characterization and In Vitro Bioactivity of Magnetite Nanoparticles Obtained by Co-Precipitation.Journal of functional biomaterials · 2026Article
- An Ion-Based Strategy Toward Synergistic Surface Functionalization Combining the Osteogenic Properties and NIR-Mediated Antibacterial Activity of PEEK.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- MAPLE Deposition of Resorbable Calcium Phosphates on Electrospun Nylon Nanofibres for Bone Tissue Engineering.Materials (Basel, Switzerland) · 2026Article
- In vitro characterization of self-assembled nanoflowers structures on Mg ZX10 for biomedical application.Medical & biological engineering & computing · 2026Article
- Simulated Body Fluids for Dental Implant Corrosion: A Practical Guide.Dentistry journal · 2026Review
- Hybrid Isoxazole-Hydroxyapatite composites as antimicrobial agents: integrated in silico and in vitro investigation.Journal of materials science. Materials in medicine · 2026Article
- Polymethyl methacrylate-hydroxyapatite: A viable non-metallic alternative for dental implants? Comprehensive surface characterization.Journal of Taibah University Medical Sciences · 2026Article
- Bioactive restorative materials in dentistry: a comprehensive review of mechanisms, clinical applications, and future directions.Odontology · 2026Review
- Sol-Gel Synthesis of New Bioactive Organic-Inorganic Materials for Biomedical Use: SiOInternational journal of molecular sciences · 2026Article
- Article
- Bioactive glass-based core-shell nanoparticles: Multifunctional platforms for controlled drug release and biomedical applications.Materials today. Bio · 2026Review
- Dual-layer biphasic calcium phosphates/tantalum pentoxide coating on titanium for concurrent biocorrosion resistance and enhanced biocompatibility.Journal of dental sciences · 2026Article
- Phase-Pure Hydroxyapatite/β-Tricalcium Phosphate Scaffolds from Ultra-Pure Precursors: Composition Governs Porosity, Strength, and SBF Kinetics.Journal of functional biomaterials · 2025Article
- Fluorinated graphene-modified biodentine: an in vitro study on its ion release, cell growth, differentiation potential, and compressive strength.BMC oral health · 2025Article
- Bone Graft Paste Nanohydroxyapatite Chitosan-Gelatin (nHA/KG) for Periodontal Regeneration: Study on Three-Dimensional Cell Culture.European journal of dentistry · 2025Article
- Evaluation of Biocompatible and Biodegradable PES/PCL Membranes for Potential Use in Biomedical Devices: From Fouling Resistance to Environmental Safety.Molecules (Basel, Switzerland) · 2025Article
- Characterization of a Novel POx-Based Adhesive Powder for Obliterating Dead Spaces After Surgery.Bioengineering (Basel, Switzerland) · 2025Article
- The Assessment of Bioactivity and Biological Responsiveness in Bioactive Glasses and Ceramics: A Review of Available Techniques.Materials (Basel, Switzerland) · 2025Review
- Graded Hydroxyapatite Triply Periodic Minimal Surface Structures for Bone Tissue Engineering Applications.Advanced healthcare materials · 2025Article
- Effect of Phosphate Phase Incorporation on 3D-Printed Hydrogel Scaffolds: Towards Customizable Bone Graft Materials.Gels (Basel, Switzerland) · 2025Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some special implantable materials are defined as "bioactive" if they can bond to living bone, forming a tight and chemically-stable interface. This property, which is inherent to some glass compositions, or can be induced by applying appropriate surface treatments on otherwise bio-inert metals, can be evaluated in vitro by immersion studies in simulated body fluid (SBF), mimicking the composition of human plasma. As a result, apatite coating may form on the material surface, and the presence of this bone-like "biomimetic skin" is considered predictive of bone-bonding ability in vivo. This review article summarizes the story and evolution of in vitro bioactivity testing methods using SBF, highlighting the influence of testing parameters (e.g., formulation and circulation of the solution) and material-related parameters (e.g., composition, geometry, texture). Suggestions for future methodological refinements are also provided at the end of the paper.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.