Evidence map›Paper›PMID 33138244›Full record

ArticleInternational journal of molecular sciences2020

Retbindin: A riboflavin Binding Protein, Is Critical for Photoreceptor Homeostasis and Survival in Models of Retinal Degeneration.

Ayse M Genc, Mustafa S Makia, Tirthankar Sinha, Shannon M Conley, Muayyad R Al-Ubaidi, Muna I Naash

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Retbindin Dynamically Redistributes to Preserve Retinal Flavin-Dependent Homeostasis in Response to Riboflavin Availability and Circadian Demand.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Article
  3. Riboflavin, Retbindin, and Riboflavin Transporters in the Retina.Advances in experimental medicine and biology · 2025
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ayse M GencDepartment of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.
Mustafa S MakiaDepartment of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.ORCID 0000-0003-3194-3274
Tirthankar SinhaDepartment of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.ORCID 0000-0002-7138-0907
Shannon M ConleyDepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Muayyad R Al-UbaidiDepartment of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.
Muna I NaashDepartment of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.
University of Houston · USCenter for Neurosciences · US

Funding

Supplement for: Mechanism of Photoreceptor Cell Degeneration in Animal Models of Retinal DiseasesR01EY010609 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI MUAYYAD R AL-UBAIDI, Muna I. Naash · 1995 to 2026
$11.0M
Role of retbindin in retinal homeostasis and diseasesR01EY026499 · NEI · UNIVERSITY OF HOUSTON · PI AL-UBAIDI, MUAYYAD R, NAASH, MUNA I. · 2017 to 2019
$1.1M
national institute of helath GM125528NEI NIH HHS EY026499, EY10609NEI NIH HHS R01 EY010609NEI NIH HHS R01 EY026499
6 · The paper itself

Abstract

The large number of inherited retinal disease genes (IRD), including the photopigment rhodopsin and the photoreceptor outer segment (OS) structural component peripherin 2 (PRPH2), has prompted interest in identifying common cellular mechanisms involved in degeneration. Although metabolic dysregulation has been shown to play an important role in the progression of the disease etiology, identifying a common regulator that can preserve the metabolic ecosystem is needed for future development of neuroprotective treatments. Here, we investigated whether retbindin (RTBDN), a rod-specific protein with riboflavin binding capability, and a regulator of riboflavin-derived cofactors flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), is protective to the retina in different IRD models; one carrying the P23H mutation in rhodopsin (which causes retinitis pigmentosa) and one carrying the Y141C mutation in

Indexed as

MutationAnimalsDisease Models, AnimalEye ProteinsFemaleHomeostasisMaleMiceMice, Inbred C57BLMice, KnockoutPeripherinsPhotoreceptor Cells, VertebrateRetinaRetinal Degenerationrho GTP-Binding ProteinsEye ProteinsPeripherinsPrph2 protein, mouserho GTP-Binding ProteinsRTBDN protein, mouseflavoproteinsinherited retinal degenerationmetabolismPrph2retinal degenerationrhodopsinriboflavin

Identifiers

PMID33138244
PMCPMC7662319
OpenAlexW3094644775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.