Evidence map›Paper›PMID 33138083›Full record

ArticleInternational journal of molecular sciences2020

Activation of RAS Signalling is Associated with Altered Cell Adhesion in Phaeochromocytoma.

Hugo M Rossitti, Ravi Kumar Dutta, Catharina Larsson, Hans K Ghayee, Peter Söderkvist, Oliver Gimm

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Case report: Two sisters with a germlineFrontiers in endocrinology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Hugo M RossittiDepartment of Biomedical and Clinical Sciences, Linköping University, SE-58183 Linköping, Sweden.ORCID 0000-0002-3766-6258
Ravi Kumar DuttaDepartment of Biomedical and Clinical Sciences, Linköping University, SE-58183 Linköping, Sweden.
Catharina LarssonDepartment of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, Cancer Center Karolinska, SE-17176 Stockholm, Sweden.
Hans K GhayeeDivision of Endocrinology, University of Florida and the Malcolm Randall VAMC, Gainesville, FL 32608, USA.
Peter SöderkvistDepartment of Biomedical and Clinical Sciences, Linköping University, SE-58183 Linköping, Sweden.
Oliver GimmDepartment of Surgery and Department of Biomedical and Clinical Sciences, Linköping University, SE-58183 Linköping, Sweden.ORCID 0000-0002-0054-664X
Linköping University · SEKarolinska University Hospital · SEUniversity of Florida · US

Funding

ALF Grants, Region Östergötland, Sweden LIO-532021Forskningsrådet i Sydöstra Sverige FORSS-481781
6 · The paper itself

Abstract

Phaeochromocytomas and paragangliomas (PPGLs) are neuroendocrine catecholamine-producing tumours that may progress into inoperable metastatic disease. Treatment options for metastatic disease are limited, indicating a need for functional studies to identify pharmacologically targetable pathophysiological mechanisms, which require biologically relevant experimental models. Recently, a human progenitor phaeochromocytoma cell line named "hPheo1" was established, but its genotype has not been characterised. Performing exome sequencing analysis, we identified a

Indexed as

Cell AdhesionGene Expression Regulation, NeoplasticAdrenal Gland NeoplasmsBiomarkers, TumorGene Expression ProfilingGTP PhosphohydrolasesHumansMembrane ProteinsPheochromocytomaPrognosisRNA, Small InterferingTumor Cells, CulturedBiomarkers, TumorGTP PhosphohydrolasesMembrane ProteinsNRAS protein, humanRNA, Small Interferingadhesionextracellular matrixhPheo1NRASparagangliomaphaeochromocytoma

Identifiers

PMID33138083
PMCPMC7663737
OpenAlexW3096198248

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.