Evidence map›Paper›PMID 33138082›Full record

ArticleInternational journal of environmental research and public health2020

Environmental Risk Factors for Early-Onset Alzheimer's Dementia and Frontotemporal Dementia: A Case-Control Study in Northern Italy.

Giorgia Adani, Tommaso Filippini, Caterina Garuti, Marcella Malavolti, Giulia Vinceti, Giovanna Zamboni, Manuela Tondelli, Chiara Galli, Manuela Costa, Marco Vinceti and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 5 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 5 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Neurodegenerative Disease and Association Football (NDAF): Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2025
    Pooled it
  3. Pooled it
  4. A systematic review on the risk of neurodegenerative diseases and neurocognitive disorders in professional and varsity athletes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Pooled it
  5. Pooled it
  6. Review
  7. Traumatic brain injury and risk of early-onset dementia: A population-based cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  8. Review
  9. Review
  10. Article
  11. Environmental toxins in neurodegeneration - a narrative review.Neurological research and practice · 2025
    Review
  12. Review
  13. Review
  14. Herbicide-related health risks: key mechanisms and a guide to mitigation strategies.Journal of occupational medicine and toxicology (London, England) · 2025
    Review
  15. Article
  16. Article
  17. Review
  18. Atrial Fibrillation and Other Cardiovascular Factors and the Risk of Dementia: An Italian Case-Control Study.International journal of environmental research and public health · 2024
    Article
  19. Peripheral HMGB1 is linked to OAlzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Giorgia AdaniEnvironmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Tommaso FilippiniEnvironmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0003-2100-0344
Caterina GarutiEnvironmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0001-6242-531X
Marcella MalavoltiEnvironmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0002-1719-7204
Giulia VincetiCenter for Neurosciences and Neurotechnology, Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, 41126 Modena, Italy.
Giovanna ZamboniCenter for Neurosciences and Neurotechnology, Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, 41126 Modena, Italy.ORCID 0000-0002-6133-3373
Manuela TondelliNeurology Unit, Modena Policlinico-University Hospital, 41126 Modena, Italy.
Chiara GalliNeurology Unit, Modena Policlinico-University Hospital, 41126 Modena, Italy.
Manuela CostaNeurology Unit of Carpi Hospital, Modena Local Health Authority, 41012 Carpi, Italy.
Marco VincetiEnvironmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0002-0551-2473
Annalisa ChiariNeurology Unit, Modena Policlinico-University Hospital, 41126 Modena, Italy.
University of Modena and Reggio Emilia · ITAzienda Unita' Sanitaria Locale Di Modena · ITAzienda Ospedaliero-Universitaria di Modena · ITBoston University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Residence CharacteristicsAdultAgedAlzheimer DiseaseCase-Control StudiesEnvironmental ExposureFemaleFrontotemporal DementiaHumansItalyLife StyleMaleMiddle AgedOccupational ExposureRisk FactorsSeleniumSeleniumAlzheimer’s dementiaearly-onset dementiaenvironmental factorsepidemiologyfrontotemporal dementiaoccupational factorsriskselenium

Identifiers

PMID33138082
PMCPMC7663191
OpenAlexW3097900845

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.