Evidence map›Paper›PMID 33138062›Full record

ArticleMarine drugs2020

Marine-Derived

Amanda Mara Teles, Leticia Prince Pereira Pontes, Sulayne Janayna Araújo Guimarães, Ana Luiza Butarelli, Gabriel Xavier Silva, Flavia Raquel Fernandes do Nascimento, Geusa Felipa de Barros Bezerra, Carla Junqueira Moragas-Tellis, Rui Miguel Gil da Costa, Marcos Antonio Custódio Neto da Silva and 4 more

Abstract read
In one paragraph

Article in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Exogenous prostaglandin DFrontiers in veterinary science · 2025
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Amanda Mara TelesLaboratory for Culture Cell, Postgraduate Program in Biotechnology (RENORBIO), Federal University of Maranhão, São Luís 65080-085, Maranhão, Brazil.
Leticia Prince Pereira PontesLaboratory of Applied Cancer Immunology, Biological and Health Sciences Center, Federal University of Maranhão, Avenida dos Portugueses, 1966 Bacanga, São Luis 65080-085, Maranhão, Brazil.
Sulayne Janayna Araújo GuimarãesLaboratory of Applied Cancer Immunology, Biological and Health Sciences Center, Federal University of Maranhão, Avenida dos Portugueses, 1966 Bacanga, São Luis 65080-085, Maranhão, Brazil.ORCID 0000-0003-3255-5281
Ana Luiza ButarelliLaboratory of Applied Cancer Immunology, Biological and Health Sciences Center, Federal University of Maranhão, Avenida dos Portugueses, 1966 Bacanga, São Luis 65080-085, Maranhão, Brazil.
Gabriel Xavier SilvaLaboratory for Culture Cell, Postgraduate Program in Biotechnology (RENORBIO), Federal University of Maranhão, São Luís 65080-085, Maranhão, Brazil.
Flavia Raquel Fernandes do NascimentoImmunophisiology Laboratory, Biological and Health Sciences Center, Federal University of Maranhão, Avenida dos Portugueses, 1966 Bacanga, São Luís 65080-085, Maranhão, Brazil.
Geusa Felipa de Barros BezerraPostgraduate Program in Adult Health (PPGSAD), Federal University of Maranhão, Avenida dos Portugueses, 1966 Bacanga, São Luís 65080-085, Maranhão, Brazil.
Carla Junqueira Moragas-TellisLaboratory of Natural Products for Public Health, Institute of Pharmaceutical Techonology, Oswaldo Cruz Foundation, Rio de Janeiro 21041-000, Brazil.
Rui Miguel Gil da CostaPostgraduate Program in Adult Health (PPGSAD), Federal University of Maranhão, Avenida dos Portugueses, 1966 Bacanga, São Luís 65080-085, Maranhão, Brazil.ORCID 0000-0002-2151-2449
Marcos Antonio Custódio Neto da SilvaPost-graduation in Internal Medicine, State University of Campinas, Campinas 13083-887, São Paulo, Brazil.
Fernando Almeida-SouzaLaboratory of Anamotopathology, Postgraduate Program in Animal Science, State University of Maranhão, São Luis 65055-310, Maranhão, Brazil.ORCID 0000-0003-0047-6159
Kátia da Silva CalabreseLaboratory of Immunomodulation and Protozoology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil.
Ana Paula Silva Azevedo-SantosLaboratory of Applied Cancer Immunology, Biological and Health Sciences Center, Federal University of Maranhão, Avenida dos Portugueses, 1966 Bacanga, São Luis 65080-085, Maranhão, Brazil.ORCID 0000-0003-2783-362X
Maria do Desterro Soares Brandão NascimentoPostgraduate Program in Adult Health (PPGSAD), Federal University of Maranhão, Avenida dos Portugueses, 1966 Bacanga, São Luís 65080-085, Maranhão, Brazil.

Funding

Foundation for the Support of Research and Scientific and Technological Development of Maranhão (FAPEMA). 031/2016
6 · The paper itself

Abstract

backgroundThis study addresses the antitumoral properties of

methodsEthyl Acetate Extracellular Extract (EAE) was used. The metabolites were studied using direct infusion mass spectrometry. The solid Ehrlich tumor model was used for antitumor activity. Female Swiss mice were divided into groups (

resultsThe extract was rich in meroterpenoids. All doses significantly reduced tumor size, and the 20 and 100 mg/kg doses reduced tumor-associated inflammation and tumor necrosis. The extract also reduced the cellular infiltration of lymphoid organs and circulating TNF-α levels. The extract did not induce weight loss or renal and hepatic toxic changes.

conclusionsThese results indicate that

Indexed as

AnimalsAntineoplastic AgentsCarcinoma, Ehrlich TumorCytokinesFemaleInflammation MediatorsMiceMolecular StructureTalaromycesTumor BurdenWater MicrobiologyAntineoplastic AgentsCytokinesInflammation MediatorsantitumorEhlich’s tumorinflammationmeroterpenoidsP. purpurogenum

Identifiers

PMID33138062
PMCPMC7694122

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.