Evidence map›Paper›PMID 33137935›Full record

ArticleGenes2020

WNT11-Conditioned Medium Promotes Angiogenesis through the Activation of Non-Canonical WNT-PKC-JNK Signaling Pathway.

Jingcai Wang, Min Gong, Shi Zuo, Jie Xu, Chris Paul, Hongxia Li, Min Liu, Yi-Gang Wang, Muhammad Ashraf, Meifeng Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jingcai WangDepartment of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA.
Min GongDepartment of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA.
Shi ZuoDepartment of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA.
Jie XuDepartment of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA.
Chris PaulDepartment of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA.
Hongxia LiDepartment of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA.
Min LiuDepartment of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA.
Yi-Gang WangDepartment of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA.
Muhammad AshrafDepartment of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA.
Meifeng XuDepartment of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA.
University of Cincinnati Medical Center · USUniversity of Cincinnati · US

Funding

Lipid profile, lipoprotein and apolipoprotein composition, and intestinal fat absorption efficiency in germ-free and conventional miceU2CDK059630 · NIDDK · UNIVERSITY OF CINCINNATI · PI LIU, MIN · 2016 to 2021
$4.9M
Role of the GI lymphatic system in hormonal signaling and nutrient metabolismR01DK119135 · NIDDK · UNIVERSITY OF CINCINNATI · PI LIU, MIN, TSO, PATRICK · 2018 to 2022
$3.0M
MicroRNA as mediators of angiogenesis & ischemic myocardial repairR01HL114654 · NHLBI · UNIVERSITY OF CINCINNATI · PI ASHRAF, MUHAMMAD, XU, MEIFENG · 2012 to 2016
$2.5M
The therapeutic potential of smarter exosomes derived from engineered MSCs on Alzheimer's diseaseR01HL140962 · NHLBI · UNIVERSITY OF CINCINNATI · PI LIU, MIN, XU, MEIFENG · 2018 to 2021
$2.4M
Wnt11 signaling in stem cell survival and cardiac regenerationR01HL105176 · NHLBI · UNIVERSITY OF CINCINNATI · PI ASHRAF, MUHAMMAD, JONES, WALTER KEITH · 2010 to 2014
$1.9M
NHLBI NIH HHS R01 HL105176NHLBI NIH HHS R01 HL114654NHLBI NIH HHS R01 HL140962NIDDK NIH HHS R01 DK119135NIDDK NIH HHS U2C DK059630
6 · The paper itself

Abstract

backgroundWe demonstrated that the transduction of Wnt11 into mesenchymal stem cells (MSCs) (MSC METHODS AND

resultsConditioned medium was collected from MSC

conclusionWnt11 released from MSC

Indexed as

Neovascularization, PhysiologicWnt Signaling PathwayAnimalsCapillariesCells, CulturedCulture Media, ConditionedDisease Models, AnimalFemaleHumansHuman Umbilical Vein Endothelial CellsMAP Kinase Signaling SystemMesenchymal Stem CellsMyocardial InfarctionProtein Kinase CRatsRats, Sprague-DawleyCulture Media, ConditionedProtein Kinase CRecombinant ProteinsWnt11 protein, humanWnt11 protein, ratWnt Proteinsangiogenesisischemic myocardiummesenchymal stem cellsWnt11Wnt-PKC-JNK pathways

Identifiers

PMID33137935
PMCPMC7694138
OpenAlexW3096002311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.