ReviewNutrients2020
Insulin Resistance in Obese Children: What Can Metabolomics and Adipokine Modelling Contribute?
Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Paediatric obesity: a systematic review and pathway mapping of metabolic alterations underlying early disease processes.Molecular medicine (Cambridge, Mass.) · 2021Pooled it
- 20/ (fasting C-peptide × fasting plasma glucose) as a novel marker for insulin resistance in obese children and adolescents.Pediatric research · 2026Article
- Metabolic risk profiling in childhood obesity through hormonal dysfunction and genetic variants: findings from a retrospective study.BMC endocrine disorders · 2026Article
- MASLD In Children - A Distinct Phenotype?Current obesity reports · 2026Review
- Metabolic features in plasma and urine of obese children and their association with MAFLD risk.Frontiers in nutrition · 2026Article
- Insulin resistance in obese children and adolescents: from mechanisms to screening and exercise intervention.Frontiers in pediatrics · 2026Review
- Article
- Exploring Salivary Biomarkers in Pediatric Obesity: A Scoping Review.International journal of molecular sciences · 2025Article
- Relationship between inflammatory biomarkers and insulin resistance in excess-weight Latin children.Clinical and experimental pediatrics · 2024Article
- Childhood Obesity and the Cryptic Language of the Microbiota: Metabolomics' Upgrading.Metabolites · 2023Review
- Identifying subgroups of childhood obesity by using multiplatform metabotyping.Frontiers in molecular biosciences · 2023Article
- Metabolomic signatures of low- and high-adiposity neonates differ based on maternal BMI.American journal of physiology. Endocrinology and metabolism · 2022Article
- Insulin resistance, leptin and adiponectin in lean and hypothyroid children and adolescents with obesity.BMC pediatrics · 2022Article
- Metabolic Status of Lean and Obese Zucker Rats Based on Untargeted and Targeted Metabolomics Analysis of Serum.Biomedicines · 2022Article
- An update of the consensus statement on insulin resistance in children 2010.Frontiers in endocrinology · 2022Review
- Omics era in type 2 diabetes: From childhood to adulthood.World journal of diabetes · 2021Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The evolution of obesity and its resulting comorbidities differs depending upon the age of the subject. The dramatic rise in childhood obesity has resulted in specific needs in defining obesity-associated entities with this disease. Indeed, even the definition of obesity differs for pediatric patients from that employed in adults. Regardless of age, one of the earliest metabolic complications observed in obesity involves perturbations in glucose metabolism that can eventually lead to type 2 diabetes. In children, the incidence of type 2 diabetes is infrequent compared to that observed in adults, even with the same degree of obesity. In contrast, insulin resistance is reported to be frequently observed in children and adolescents with obesity. As this condition can be prerequisite to further metabolic complications, identification of biological markers as predictive risk factors would be of tremendous clinical utility. Analysis of obesity-induced modifications of the adipokine profile has been one classic approach in the identification of biomarkers. Recent studies emphasize the utility of metabolomics in the analysis of metabolic characteristics in children with obesity with or without insulin resistance. These studies have been performed with targeted or untargeted approaches, employing different methodologies. This review summarizes some of the advances in this field while emphasizing the importance of the different techniques employed.
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