Evidence map›Paper›PMID 33137883›Full record

ArticleJournal of clinical medicine2020

Inflammation of Conduction Tissue in Patients with Arrhythmic Phenotype of Myocarditis.

Andrea Frustaci, Romina Verardo, Maria Alfarano, Cristina Chimenti

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 78% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Andrea FrustaciDepartment of Clinical, Internal, Anesthesiologist and Cardiovascular Sciences, Sapienza University, 00161 Rome, Italy.
Romina VerardoCellular and Molecular Cardiology Lab, IRCCS L. Spallanzani, 00149 Rome, Italy.
Maria AlfaranoDepartment of Clinical, Internal, Anesthesiologist and Cardiovascular Sciences, Sapienza University, 00161 Rome, Italy.
Cristina ChimentiDepartment of Clinical, Internal, Anesthesiologist and Cardiovascular Sciences, Sapienza University, 00161 Rome, Italy.
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMyocarditis can manifest with lone ventricular tachyarrhythmias (LVT). Elective inflammation of conduction tissue (CT) is supposed but unproved.

methodsForty-two of 420 patients with biopsy proven myocarditis presented with LVT. Twelve of them included CT sections in endomyocardial biopsies. Real-time polymerase chain reaction (PCR) for viral genomes, immunohistochemistry for viral antigens and Toll like receptor 4 (TLR4) were performed. Twelve myocarditis patients with infarct-like or cardiomyopathic phenotype and CT included in tissue section were used as controls.

resultsFour of the 12 patients presented non-sustained ventricular tachycardia (nsVT), six with sustained ventricular tachycardia (sVT), two with ventricular fibrillation. CT was inflamed in all LVT patients and not in controls (

conclusionsArrhythmic phenotype of myocarditis is associated with CT inflammation/infection. Molecular characterization of CT damage may lead to pharmacologic control of arrhythmias in 75% of cases.

Indexed as

arrhythmic phenotypeconduction tissuemyocarditis

Identifiers

PMID33137883
PMCPMC7693374
OpenAlexW3095163793

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.