Evidence map›Paper›PMID 33137644›Full record

ArticlePlacenta2021

PlacentaCellEnrich: A tool to characterize gene sets using placenta cell-specific gene enrichment analysis.

Ashish Jain, Geetu Tuteja

Open access · greenAbstract read
In one paragraph

Article in Placenta, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 37 citations in OpenAlex.

  1. celltypeEnrich: a consensus-based scRNA-seq cluster annotation tool.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Plasma cell-free extrachromosomal circular DNA is a molecular hallmark of preeclampsia.Computational and structural biotechnology journal · 2025
    Article
  6. Article
  7. Effects of oxycodone on placental lineages: Evidence from the transcriptome profile of mouse trophoblast giant cells.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. PRO-Simat: Protein network simulation and design tool.Computational and structural biotechnology journal · 2023
    Article
  20. Conservation at the uterine-placental interface.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ashish JainBioinformatics and Computational Biology, Iowa State University, Ames, IA, 50010-1079, USA; Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, 50010-1079, USA.
Geetu TutejaBioinformatics and Computational Biology, Iowa State University, Ames, IA, 50010-1079, USA; Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, 50010-1079, USA. Electronic address: geetu@iastate.edu.
Iowa State University · US

Funding

Transcriptional regulatory networks govering placental development.R01HD096083 · NICHD · IOWA STATE UNIVERSITY · PI TUTEJA, GEETU · 2018 to 2022
$1.5M
Trophoblast-Uterine Cell Dynamics at the Maternal-Fetal InterfaceR21HD104033 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SOARES, MICHAEL J, TUTEJA, GEETU · 2020 to 2021
$424k
NICHD NIH HHS R01 HD096083NICHD NIH HHS R21 HD104033
6 · The paper itself

Abstract

Single-cell RNA-Sequencing (scRNA-Seq) has improved our understanding of individual cell types in the human placenta. However, placental scRNA-Seq data is not readily accessible when trying to understand how expression patterns in model systems correspond to those from first trimester human placenta. Therefore, we developed PlacentaCellEnrich, a tool that takes a gene set as input, and then reports if the input set is enriched for genes with placenta cell-specific expression patterns, based on human placenta scRNA-Seq data. The PlacentaCellEnrich tool is freely available at https://placentacellenrich.gdcb.iastate.edu/ for non-profit academic use under the MIT license.

Indexed as

PlacentaAlgorithmsFemaleGene Expression ProfilingHigh-Throughput Nucleotide SequencingHumansOrgan SpecificityPregnancyRNARNA-SeqSequence Analysis, RNASingle-Cell AnalysisSoftwareRNACell subtype identificationDeciduaGene enrichmentscRNA-seqTrophoblast

Identifiers

PMID33137644
PMCPMC7920947
OpenAlexW3095295339

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.