Evidence map›Paper›PMID 33137603›Full record

ArticleBiomaterials2021

Nanoengineered shear-thinning and bioprintable hydrogel as a versatile platform for biomedical applications.

Nooshin Zandi, Ehsan Shirzaei Sani, Ebrahim Mostafavi, Dina M Ibrahim, Bahram Saleh, Mohammad Ali Shokrgozar, Elnaz Tamjid, Paul S Weiss, Abdolreza Simchi, Nasim Annabi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 148 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Bioactive Inorganic Materials for Innervated Multi-Tissue Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  17. Review
  18. Review
  19. Review
  20. Droplet-based bioprinting.Nature reviews. Methods primers · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Nooshin ZandiInstitute for Nanoscience and Nanotechnology, Sharif University of Technology, P.O. Box 11365-11155, Tehran, Iran; Department of Chemical Engineering, Northeastern University, Boston, Massachuestts, 02115, United States.
Ehsan Shirzaei SaniDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, United States.
Ebrahim MostafaviDepartment of Chemical Engineering, Northeastern University, Boston, Massachuestts, 02115, United States.
Dina M IbrahimDepartment of Chemical Engineering, Northeastern University, Boston, Massachuestts, 02115, United States; Energy Materials Laboratory (EML), School of Sciences and Engineering, The American University in Cairo, New Cairo 11835, Egypt.
Bahram SalehDepartment of Chemical Engineering, Northeastern University, Boston, Massachuestts, 02115, United States.
Mohammad Ali ShokrgozarNational Cell Bank Department, Pasteur Institute of Iran, Tehran, 13164, Iran.
Elnaz TamjidDepartment of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran.
Paul S WeissDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, 90095, United States; California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, United States; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, United States; Department of Materials Science and Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, United States; Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute (CNSI), University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA, 90095, United States.
Abdolreza SimchiInstitute for Nanoscience and Nanotechnology, Sharif University of Technology, P.O. Box 11365-11155, Tehran, Iran; Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute (CNSI), University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA, 90095, United States. Electronic address: simchi@sharif.edu.
Nasim AnnabiDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, United States; Department of Materials Science and Engineering, Sharif University of Technology, P.O. Box 11365-11155, Tehran, Iran. Electronic address: nannabi@ucla.edu.
Northeastern University · USSharif University of Technology · IRUniversity of California, Los Angeles · USCalifornia NanoSystems Institute · USPasteur Institute of Iran · IRTarbiat Modares University · IR

Funding

Engineering highly elastic surgical sealants with hemostatic propertiesR01HL140618 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANNABI, NASIM, KHADEMHOSSEINI, ALI · 2018 to 2021
$2.8M
Engineering a naturally derived and highly adhesive surgical sealantR01EB023052 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANNABI, NASIM, KHADEMHOSSEINI, ALI · 2017 to 2022
$2.4M
NHLBI NIH HHS R01 HL140618NIBIB NIH HHS R01 EB023052
6 · The paper itself

Abstract

The development of bioinks based on shear-thinning and self-healing hydrogels has recently attracted significant attention for constructing complex three-dimensional physiological microenvironments. For extrusion-based bioprinting, it is challenging to provide high structural reliability and resolution of printed structures while protecting cells from shear forces during printing. Herein, we present shear-thinning and printable hydrogels based on silicate nanomaterials, laponite (LA), and glycosaminoglycan nanoparticles (GAGNPs) for bioprinting applications. Nanocomposite hydrogels (GLgels) were rapidly formed within seconds due to the interactions between the negatively charged groups of GAGNPs and the edges of LA. The shear-thinning behavior of the hydrogel protected encapsulated cells from aggressive shear stresses during bioprinting. The bioinks could be printed straightforwardly into shape-persistent and free-standing structures with high aspect ratios. Rheological studies demonstrated fast recovery of GLgels over multiple strain cycles. In vitro studies confirmed the ability of GLgels to support cell growth, proliferation, and spreading. In vitro osteogenic differentiation of pre-osteoblasts murine bone marrow stromal cells encapsulated inside the GLgels was also demonstrated through evaluation of ALP activity and calcium deposition. The subcutaneous implantation of the GLgel in rats confirmed its in vivo biocompatibility and biodegradability. The engineered shear-thinning hydrogel with osteoinductive characteristics can be used as a new bioink for 3D printing of constructs for bone tissue engineering applications.

Indexed as

BioprintingHydrogelsAnimalsMiceOsteogenesisPrinting, Three-DimensionalRatsReproducibility of ResultsTissue EngineeringTissue ScaffoldsHydrogels3D bioprintingBiomimetic proteoglycanLaponiteNanocompositeOsteoinductive bioink

Identifiers

PMID33137603
PMCPMC7846391
OpenAlexW3093317207

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.