Evidence map›Paper›PMID 33137399›Full record

ArticleBehavioural brain research2021

Disruption of metabolic, sleep, and sensorimotor functional outcomes in a female transgenic mouse model of Alzheimer's disease.

Divine C Nwafor, Sreeparna Chakraborty, Sujung Jun, Allison L Brichacek, Margaret Dransfeld, Darren E Gemoets, Duaa Dakhlallah, Candice M Brown

Open access · greenAbstract read
In one paragraph

Article in Behavioural brain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Divine C NwaforDepartment of Neuroscience, School of Medicine, West Virginia University, Morgantown, WV 26506, USA.
Sreeparna ChakrabortyDepartment of Microbiology, Immunology, and Cell Biology, School of Medicine, West Virginia University, Morgantown, WV 26506, USA.
Sujung JunDepartment of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, WV 26506, USA.
Allison L BrichacekDepartment of Microbiology, Immunology, and Cell Biology, School of Medicine, West Virginia University, Morgantown, WV 26506, USA.
Margaret DransfeldDepartment of Neuroscience, School of Medicine, West Virginia University, Morgantown, WV 26506, USA.
Darren E GemoetsDepartment of Biostatistics, School of Public Health, West Virginia University, Morgantown, WV 26506 USA.
Duaa DakhlallahDepartment of Neuroscience, School of Medicine, West Virginia University, Morgantown, WV 26506, USA; Cancer Institute, West Virginia University Health Science Center, Morgantown, WV 26506, USA.
Candice M BrownDepartment of Neuroscience, School of Medicine, West Virginia University, Morgantown, WV 26506, USA; Department of Microbiology, Immunology, and Cell Biology, School of Medicine, West Virginia University, Morgantown, WV 26506, USA; Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, USA. Electronic address: cdbrown2@hsc.wvu.edu.
West Virginia University · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Sally Lynn Hodder · 2012 to 2026
$81.0M
West Virginia University Stroke COBREP20GM109098 · NIGMS · WEST VIRGINIA UNIVERSITY · PI HRUSKA, MARTIN · 2014 to 2024
$24.5M
Stroke and Alzheimers Disease Related DementiasT32AG052375 · NIA · WEST VIRGINIA UNIVERSITY · PI Paul D Chantler, BERNARD G. SCHREURS · 2017 to 2026
$3.5M
Estradiol Regulation of Brain-Microvascular Inflammatory Responses in SepsisK01NS081014 · NINDS · WEST VIRGINIA UNIVERSITY · PI BROWN, CANDICE · 2012 to 2016
$714k
NIA NIH HHS T32 AG052375NIGMS NIH HHS P20 GM109098NIGMS NIH HHS U54 GM104942NINDS NIH HHS K01 NS081014
6 · The paper itself

Abstract

Alzheimer's Disease (AD) is the most prevalent form of dementia globally, and the number of individuals with AD diagnosis is expected to double by 2050. Numerous preclinical AD studies have shown that AD neuropathology accompanies alteration in learning and memory. However, less attention has been given to alterations in metabolism, sleep, and sensorimotor functional outcomes during AD pathogenesis. The objective of this study was to elucidate the extent to which metabolic activity, sleep-wake cycle, and sensorimotor function is impaired in APPSwDI/Nos2

Indexed as

Alzheimer DiseaseAnimalsBehavior, AnimalDisease Models, AnimalEnergy MetabolismFemaleLocomotionMiceMice, Inbred C57BLMice, TransgenicNociceptionSleep Wake DisordersThermosensingAlzheimer’s diseaseMetabolismNeuroinflammationSensorimotorSleep

Identifiers

PMID33137399
PMCPMC7719580
OpenAlexW3096825434

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.