Evidence map›Paper›PMID 33136553›Full record

ArticleAging2020

Melatonin exerts immunoregulatory effects by balancing peripheral effector and regulatory T helper cells in myasthenia gravis.

Ting Chang, Chunxiao Niu, Chao Sun, Ying Ma, Rongjing Guo, Zhe Ruan, Yanwu Gao, Xiaodan Lu, Huanhuan Li, Ye Lin and 2 more

Open access · greenAbstract read
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
15.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Association ofInternational journal of molecular sciences · 2025
    Article
  4. Melatonin, an Antitumor Necrosis Factor Therapy.Journal of pineal research · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Ting ChangDepartment of Neurology, Tangdu Hospital, The Air Force Medical University, Xi’an, Shaanxi Province, P.R. China.
Chunxiao NiuDepartment of Neurology, Tangdu Hospital, The Air Force Medical University, Xi’an, Shaanxi Province, P.R. China.
Chao SunDepartment of Neurology, Tangdu Hospital, The Air Force Medical University, Xi’an, Shaanxi Province, P.R. China.
Ying MaDepartment of Immunology, The Air Force Medical University, Xi’an, Shaanxi Province, P.R. China.
Rongjing GuoDepartment of Neurology, Tangdu Hospital, The Air Force Medical University, Xi’an, Shaanxi Province, P.R. China.
Zhe RuanDepartment of Neurology, Tangdu Hospital, The Air Force Medical University, Xi’an, Shaanxi Province, P.R. China.
Yanwu GaoDepartment of Neurology, Tangdu Hospital, The Air Force Medical University, Xi’an, Shaanxi Province, P.R. China.
Xiaodan LuDepartment of Neurology, Tangdu Hospital, The Air Force Medical University, Xi’an, Shaanxi Province, P.R. China.
Huanhuan LiDepartment of Neurology, Tangdu Hospital, The Air Force Medical University, Xi’an, Shaanxi Province, P.R. China.
Ye LinDepartment of Neurology, Chinese PLA General Hospital, Beijing, P.R. China.
Jiaji LinMedical Corp in Unit 93246 of PLA, Changchun, Jilin Province, P.R. China.
Zhuyi LiDepartment of Neurology, Tangdu Hospital, The Air Force Medical University, Xi’an, Shaanxi Province, P.R. China.
Tang Du Hospital · CNAir Force Medical University · CNChinese PLA General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myasthenia gravis (MG) is a prototypic organ-specific autoimmune disorder that, in most cases, is mainly mediated by antibodies against the acetylcholine receptor. Evidence implicates CD4

Indexed as

AdultAgedFemaleForkhead Transcription FactorsHumansInterleukin-10MaleMelatoninMiddle AgedMyasthenia GravisReceptor, Melatonin, MT1Th17 CellsTh1 CellsForkhead Transcription FactorsFOXP3 protein, humanInterleukin-10MelatoninReceptor, Melatonin, MT1FoxP3melatoninmelatonin receptormyasthenia gravisTh cell. regulatory T cells

Identifiers

PMID33136553
PMCPMC7695404
OpenAlexW3095681672

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.