ArticleJournal of the American Chemical Society2020
On-Demand Detachment of Succinimides on Cysteine to Facilitate (Semi)Synthesis of Challenging Proteins.
Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed, 46 citations in OpenAlex.
- Site-specific protein functionalization by late-stage reversible cysteine masking.Nature communications · 2026Article
- Total Chemical Synthesis of Interleukin-15 and Interleukin-2: Taming Protein Hydrophobicity and Aggregation by a Versatile Solubilizing Strategy.Angewandte Chemie (International ed. in English) · 2026Article
- Revealing and Exploiting the Biochemistry ofBiochemistry · 2026Review
- Native Chemical Ligation to Install Chemical Protein Modifications.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Advances in the chemical synthesis of human proteoforms.Science China. Life sciences · 2025Review
- Selective Activation of Peptide-Thioester Precursors for Templated Native Chemical Ligations.Angewandte Chemie (International ed. in English) · 2025Article
- Ruthenium-Catalyzed One-pot Peptide Ligation.Methods in molecular biology (Clifton, N.J.) · 2025Article
- A cysteine-specific solubilizing tag strategy enables efficient chemical protein synthesis of difficult targets.Chemical science · 2024Article
- HSP27 Inhibitory Activity against Caspase-3 Cleavage and Activation by Caspase-9 Is Enhanced by Chaperone O-GlcNAc ModificationACS chemical biology · 2023Article
- Towards the use of an amino acid cleavable linker for solid-phase chemical synthesis of peptides and proteins.Organic & biomolecular chemistry · 2023Article
- Cysteine-Assisted Click-Chemistry for Proximity-Driven, Site-Specific Acetylation of Histones.Angewandte Chemie (International ed. in English) · 2022Article
- Traceless enzymatic protein synthesis without ligation sites constraint.National science review · 2022Article
- Synthesis of O-GlcNAcylated small heat shock proteins.Methods in enzymology · 2022Article
- Organoruthenium-catalyzed chemical protein synthesis to elucidate the functions of epigenetic modifications on heterochromatin factors.Chemical science · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The maleimide group is a widely used reagent for bioconjugation of peptides, proteins, and oligonucleotides employing Michael addition and Diels-Alder cycloaddition reactions. However, the utility of this functionality in chemical synthesis of peptides and proteins remains unexplored. We report, for the first time that Pd
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.