Evidence map›Paper›PMID 33136287›Full record

ArticleJournal of cell communication and signaling2021

A complete map of the Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) signaling pathway.

Mohd Altaf Najar, D A B Rex, Prashant Kumar Modi, Nupur Agarwal, Shobha Dagamajalu, Gayathree Karthikkeyan, Manavalan Vijayakumar, Aditi Chatterjee, Uma Sankar, T S Keshava Prasad

Open access · greenAbstract read
In one paragraph

Article in Journal of cell communication and signaling, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
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  10. Review
  11. Impaired CAMK4 Activity Limits Atherosclerosis and Reprograms Myelopoiesis.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Potential therapeutic mechanisms ofFrontiers in pharmacology · 2025
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Mohd Altaf NajarCenter for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, 575018, India.ORCID http://orcid.org/0000-0002-3044-3772
D A B RexCenter for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, 575018, India.ORCID http://orcid.org/0000-0002-9556-3150
Prashant Kumar ModiCenter for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, 575018, India.
Nupur AgarwalCenter for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, 575018, India.ORCID http://orcid.org/0000-0002-1447-2397
Shobha DagamajaluCenter for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, 575018, India.ORCID http://orcid.org/0000-0002-0899-2839
Gayathree KarthikkeyanCenter for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, 575018, India.ORCID http://orcid.org/0000-0002-5965-2957
Manavalan VijayakumarDepartment of Surgical Oncology, Yenepoya Medical College and Hospital, Yenepoya (Deemed to be University), Mangalore, 575018, India.
Aditi ChatterjeeCenter for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, 575018, India.ORCID http://orcid.org/0000-0001-8474-5824
Uma SankarDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, 635 Barnhill Drive, MS-5055, Indianapolis, IN, 46202, USA.
T S Keshava PrasadCenter for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, 575018, India. keshav@yenepoya.edu.in.ORCID http://orcid.org/0000-0002-6206-2384
Yenepoya University · INIndiana University School of Medicine

Funding

CaMKK2 Signaling in OsteoarthritisR01AR076477 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI SANKAR, UMA · 2020 to 2024
$3.0M
CaMKK2 Inhibition as a Dual-Action Bone Anabolic and Anti-Catabolic Therapy in OsteoporosisR01AR068332 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI SANKAR, UMA · 2015 to 2019
$2.1M
NIAMS NIH HHS R01 AR068332NIAMS NIH HHS R01 AR076477
6 · The paper itself

Abstract

Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) is a serine/threonine-protein kinase belonging to the Ca

Indexed as

AdenocarcinomaCalcium signaling pathwayCAMKK2Molecular associationSignaling moduleTumorigenesis

Identifiers

PMID33136287
PMCPMC7990983
OpenAlexW3097219478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.