Evidence map›Paper›PMID 33136241›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2021

Rural-urban differences in health-related quality of life: patterns for cancer survivors compared to other older adults.

Jennifer L Moss, Casey N Pinto, Scherezade K Mama, Maria Rincon, Erin E Kent, Mandi Yu, Kathleen A Cronin

Open access · greenAbstract read
In one paragraph

Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
2.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Effectiveness of Physical Activity Interventions among Rural Cancer Survivors: A Systematic Review and Meta-Analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Pooled it
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  5. Rurality and long-term outcomes after critical illness.Annals of the American Thoracic Society · 2026
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  8. Survivorship Care Plan use by cancer survivors living in rural versus urban settings: A qualitative analysis.Canadian oncology nursing journal = Revue canadienne de nursing oncologique · 2026
    Article
  9. Canadian oncology nursing journal = Revue canadienne de nursing oncologique · 2026
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  13. Health-related quality of life trajectories in older adult long-term survivors of colorectal cancer.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
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  19. Prevalence and factors of meditation and yoga practice in the USA: How cancer and anxiety correlate.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Jennifer L MossNational Cancer Institute, Bethesda, MD, USA. jmoss1@pennstatehealth.psu.edu.ORCID http://orcid.org/0000-0002-3794-1344
Casey N PintoPenn State College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.
Scherezade K MamaThe Pennsylvania State University, University Park, PA, USA.
Maria RinconTemple University, Philadelphia, PA, USA.
Erin E KentUniversity of North Carolina, Chapel Hill, NC, USA.
Mandi YuNational Cancer Institute, Bethesda, MD, USA.
Kathleen A CroninNational Cancer Institute, Bethesda, MD, USA.
National Cancer Institute · USPennsylvania State University · USTemple University · USUniversity of North Carolina at Chapel Hill · US

Funding

Overcoming barriers to cancer screening among women living in rural and segregated communitiesK22CA225705 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI MOSS, JENNIFER LINDSAY · 2019 to 2022
$629k
Division of Cancer Prevention, National Cancer Institute Z99 CA999999NCI NIH HHS K22 CA225705NCI NIH HHS Y99 CA999999
6 · The paper itself

Abstract

purposeHealth-related quality of life (HRQOL) among older cancer survivors can be impaired by factors such as treatment, comorbidities, and social challenges. These HRQOL impairments may be especially pronounced in rural areas, where older adults have higher cancer burden and more comorbidities and risk factors for poor health. This study aimed to assess rural-urban differences in HRQOL for older cancer survivors and controls.

methodsData came from Surveillance, Epidemiology, and End Results-Medicare Health Outcomes Survey (SEER-MHOS), which links cancer incidence from 18 U.S. population-based cancer registries to survey data for Medicare Advantage Organization enrollees (1998-2014). HRQOL measures were 8 standardized subscales and 2 global summary measures. We matched (2:1) controls to breast, colorectal, lung, and prostate cancer survivors, creating an analytic dataset of 271,640 participants (ages 65+). HRQOL measures were analyzed with linear regression models including multiplicative interaction terms (rurality by cancer status), controlling for sociodemographics, cohort, and multimorbidities.

resultsHRQOL scores were higher in urban than rural areas (e.g., global physical component summary score for breast cancer survivors: urban mean = 38.7, standard error [SE] = 0.08; rural mean = 37.9, SE = 0.32; p < 0.05), and were generally lower among cancer survivors compared to controls. Rural cancer survivors had particularly poor vitality (colorectal: p = 0.05), social functioning (lung: p = 0.05), role limitation-physical (prostate: p < 0.01), role limitation-emotional (prostate: p < 0.01), and global mental component summary (prostate: p = 0.02).

conclusionSupportive interventions are needed to increase physical, social, and emotional HRQOL among older cancer survivors in rural areas. These interventions could target cancer-related stigma (particularly for lung and prostate cancers) and/or access to screening, treatment, and ancillary healthcare resources.

Indexed as

AgedCancer SurvivorsFemaleHumansMaleNeoplasmsQuality of LifeRural PopulationSurveys and QuestionnairesUrban PopulationCancer survivorshipHealth disparitiesHealth-related quality of lifeOlder adultsRuralUrban

Identifiers

PMID33136241
PMCPMC8005417
OpenAlexW3097842296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.