Evidence map›Paper›PMID 33136234›Full record

ArticleJournal of neuro-oncology2021

Awake surgery for right frontal lobe glioma can preserve visuospatial cognition and spatial working memory.

Mitsutoshi Nakada, Riho Nakajima, Hirokazu Okita, Yusuke Nakade, Takeo Yuno, Shingo Tanaka, Masashi Kinoshita

Abstract read
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In one paragraph

Article in Journal of neuro-oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 6 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 6 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mitsutoshi NakadaDepartment of Neurosurgery, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan. mnakada@med.kanazawa-u.ac.jp.ORCID http://orcid.org/0000-0001-9419-6101
Riho NakajimaDepartment of Occupational therapy, Faculty of health science, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
Hirokazu OkitaDepartment of Physical Medicine and Rehabilitation, Kanazawa University Hospital, Kanazawa, Japan.
Yusuke NakadeDepartment of Clinical Laboratory, Kanazawa University Hospital, Kanazawa, Japan.
Takeo YunoDepartment of Clinical Laboratory, Kanazawa University Hospital, Kanazawa, Japan.
Shingo TanakaDepartment of Neurosurgery, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.
Masashi KinoshitaDepartment of Neurosurgery, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.
Kanazawa University · JPKanazawa University Hospital · JP

Funding

Japan Society for the Promotion of Science 18K19606Japan Society for the Promotion of Science 19K22801Japan Society for the Promotion of Science 20K21649
6 · The paper itself

Abstract

purposeAwake surgery is the standard treatment to preserve motor and language functions. This longitudinal study aimed to evaluate the resection rate and preservation of neurocognitive functions in patients with right frontal lobe glioma who underwent awake surgery.

methodsThirty-three patients (mean age, 48.0 years) with right frontal lobe glioma who underwent awake surgery at our hospital between 2013 and 2019 were included. Fourteen, thirteen, and six cases had WHO classification grades of II, III, and IV, respectively. We evaluated visuospatial cognition (VSC) and spatial working memory (SWM) before and three months after surgery. Relevant brain areas for VSC and SWM were intraoperatively mapped, whenever the task was successfully accomplished. Therefore, patients were divided into an intraoperative evaluation group and a non-evaluation group for each function, and the resection rate and functional outcomes were compared.

resultsThe removal rate in the evaluation group for VSC and SWM were similar to that in the non-evaluation group. Chronic impairment rate of VSC was significantly lower in the evaluation than in the non-evaluation group (5.6% vs. 33.3%, p = 0.034). No patient showed postoperative SWM impairment in the evaluation group as opposed to the non-evaluation group (16.7%, p = 0.049). The probability of resection of the deeper posterior part of the middle frontal gyrus, the relevant area of VSC, was higher in the non-evaluation group than in the evaluation group.

conclusionsWe statistically verified that awake surgery for right frontal lobe glioma results in successful preservation of VSC and SWM with satisfying resection rates.

Indexed as

WakefulnessAdultBrain MappingBrain NeoplasmsCognitionFemaleFollow-Up StudiesFrontal LobeGliomaHumansIntraoperative Neurophysiological MonitoringMaleMemory, Short-TermMiddle AgedNeurosurgical ProceduresPrognosisAwake surgeryFrontal lobeGliomaVisuospatial cognitionWorking memory

Identifiers

PMID33136234
OpenAlexW3097010516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.