Evidence map›Paper›PMID 33136224›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2022

A drug-induced hypotensive challenge to verify catheter-based radiofrequency renal denervation in an obese hypertensive swine model.

Lucas Lauder, L Boyce Moon, Catherine A Pipenhagen, Sebastian Ewen, Jeffrey M Fish, Renu Virmani, James A Jensen, Michael Böhm, Felix Mahfoud

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Identifying very low-risk STEMI patients for early ICU discharge in the COVID-19 era.Clinical research in cardiology : official journal of the German Cardiac Society · 2020
    Article
  4. Impact of COVID-19 outbreak on regional STEMI care in Germany.Clinical research in cardiology : official journal of the German Cardiac Society · 2020
    Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Lucas LauderKlinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Saarland University, Kirrberger Str. 100, Geb. 41.1 (IMED), 66421, Homburg, Saar, Germany. Lucas.Lauder@uks.eu.ORCID http://orcid.org/0000-0003-1434-9556
L Boyce MoonAbbott, Inc, Plymouth, MN, USA.
Catherine A PipenhagenAbbott, Inc, Plymouth, MN, USA.
Sebastian EwenKlinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Saarland University, Kirrberger Str. 100, Geb. 41.1 (IMED), 66421, Homburg, Saar, Germany.
Jeffrey M FishAbbott, Inc, Plymouth, MN, USA.
Renu VirmaniCVPath Institute, Gaithersburg, MD, USA.
James A JensenAbbott, Inc, Plymouth, MN, USA.
Michael BöhmKlinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Saarland University, Kirrberger Str. 100, Geb. 41.1 (IMED), 66421, Homburg, Saar, Germany.
Felix MahfoudKlinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Saarland University, Kirrberger Str. 100, Geb. 41.1 (IMED), 66421, Homburg, Saar, Germany.
Abbott (United States) · USUniversitätsklinikum des Saarlandes · DECVPath Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSham-controlled trials provided proof-of-principle for the blood pressure-lowering effect of catheter-based renal denervation (RDN). However, indicators for the immediate assessment of treatment success are lacking. This study sought to investigate the impact of RDN on renal renin arteriovenous difference (renal renin AV-Δ) following a hypotensive challenge (HC).

methodsTwelve hypertensive Ossabaw swine underwent either combined surgical and chemical (n = 3) or catheter-based RDN (n = 9). A telemetry monitor was implanted to acquire hemodynamic data continuously. Before and after RDN, a sodium nitroprusside-induced HC was performed. Renal renin AV-Δ was calculated as the difference of plasma renin concentrations drawn from the renal artery and vein.

resultsIn total, complete renal renin AV data were obtained in eight animals at baseline and six animals at baseline and 3 months of follow-up. Baseline renal renin AV-Δ correlated inversely with change in 24-h minimum systolic (- 0.764, p = 0.02), diastolic (r = - 0.679, p = 0.04), and mean (r = - 0.663, p = 0.05) blood pressure. In the animals with complete renin secretion data at baseline and follow-up, the HC increased renal renin AV-Δ at baseline, while this effect was attenuated following RDN (0.55 ± 0.34 pg/ml versus - 0.10 ± 0.16 pg/ml, p = 0.003). Renin urinary excretion remained unchanged throughout the study (baseline 0.286 ± 0.187 pg/ml versus termination 0.305 ± 0.072 pg/ml, p = 0.789).

conclusionRenin secretion induced by HC was attenuated following RDN and may serve as an indicator for patient selection and guide successful RDN procedures.

Indexed as

Catheter AblationHypertensionAnimalsBlood PressureCathetersDenervationHumansKidneyObesityReninSwineSympathectomyReninArterial hypertensionHypotensive challengeRenal arterial microanatomyRenal denervation

Identifiers

PMID33136224
PMCPMC9151536
OpenAlexW3095876719

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.