Evidence map›Paper›PMID 33136000›Full record

ArticleeLife2020

Genetic timestamping of plasma cells in vivo reveals tissue-specific homeostatic population turnover.

An Qi Xu, Rita R Barbosa, Dinis Pedro Calado

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Structural promiscuity in the human circulatory IgA1 clonal repertoire.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  7. Article
  8. Review
  9. Review
  10. iScience · 2025
    Article
  11. Article
  12. Distinct autoreactive CD19Nature communications · 2025
    Article
  13. Genes · 2025
    Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

An Qi XuImmunity and Cancer, The Francis Crick Institute, London, United Kingdom.ORCID 0000-0001-8008-6462
Rita R BarbosaImmunity and Cancer, The Francis Crick Institute, London, United Kingdom.
Dinis Pedro CaladoImmunity and Cancer, The Francis Crick Institute, London, United Kingdom.ORCID 0000-0001-8239-7184
The Francis Crick Institute · GBKing's College London · GB

Funding

Cancer Research UK 26819Cancer Research UK C355/A26819Cancer Research UK FC001057Medical Research Council FC001057Medical Research Council MR/J008060/1Wellcome TrustWellcome Trust FC001057
6 · The paper itself

Abstract

Plasma cells (PCs) are essential for protection from infection, and at the origin of incurable cancers. Current studies do not circumvent the limitations of removing PCs from their microenvironment and confound formation and maintenance. Also, the investigation of PC population dynamics has mostly relied on nucleotide analog incorporation that does not label quiescent cells, a property of most PCs. The main impediment is the lack of tools to perform specific genetic manipulation in vivo. Here we characterize a genetic tool (Jchain

Indexed as

HomeostasisAnimalsBone MarrowBone Marrow CellsImmunoglobulin IsotypesMiceMice, Inbred C57BLOrgan SpecificityPlasma CellsSpleenImmunoglobulin IsotypesB cellsBlimp1cre-loxPhomeostasisimmunologyinflammationJchainmouseplasma cells

Identifiers

PMID33136000
PMCPMC7682985
OpenAlexW3097499763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.