ArticleCirculation research2021
Live Imaging of Intracranial Lymphatics in the Zebrafish.
Article in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 76 citations in OpenAlex.
- Review
- Blood and lymphatic vascular network in bone injury repair: from molecular mechanisms to therapeutic strategies.Science China. Life sciences · 2026Review
- Meningeal lymphatic dysfunction in Alzheimer's disease: molecular mechanisms, clinical implications, and future perspectives.Molecular neurodegeneration · 2026Review
- Ex vivo imaging reveals neutrophil behaviors in the adult zebrafish heart.Journal of cell science · 2026Article
- The Glymphatic System and Meningeal Lymphatics: Current Understandings and Future Perspectives.MedComm · 2026Review
- Beyond the mouse: 3R-guided alternative animal models transforming cancer research.Molecular cancer · 2026Review
- Longitudinal in vivo imaging of dynamic immune-vascular responses to meningeal cerebrovascular injury.Journal of neuroinflammation · 2026Article
- Loss of meningeal lymphatic endothelial cells results in formation of a newly forming vascular network with scavenging function.Development (Cambridge, England) · 2026Article
- Endothelial PROX1 induces blood-brain barrier disruption in the central nervous system.JCI insight · 2026Article
- Deep cervical lymph node analysis in central nervous system inflammatory disease.Frontiers in immunology · 2026Review
- Live longitudinal imaging of meningeal cerebrovascular injury and its sequelae in adult zebrafish.bioRxiv : the preprint server for biology · 2025Article
- Zebrafish Models of Induced Lymphangiogenesis: Current Advancements and Therapeutic Discovery.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Group B Streptococci lyse endothelial cells to infect the brain in a zebrafish meningitis model.PLoS biology · 2025Article
- The axillary lymphoid organ is an external, experimentally accessible immune organ in the zebrafish.The Journal of experimental medicine · 2025Article
- Compensatory lymphangiogenesis is required for edema resolution in zebrafish.Scientific reports · 2025Article
- Brain penetration of peripheral extracellular vesicles from Alzheimer's patients and induction of microglia activation.Journal of extracellular biology · 2025Article
- Cerebrovascular ageing: how zebrafish can contribute to solving the puzzle.Frontiers in physiology · 2025Article
- Knowns and unknowns of TiLV-associated neuronal disease.Virulence · 2024Review
- dab2 is required for the scavenging function of lymphatic endothelial cells in the zebrafish meninges.Scientific reports · 2024Article
- Meningeal Lymphatics in Central Nervous System Diseases.Annual review of neuroscience · 2024Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
rationaleThe recent discovery of meningeal lymphatics in mammals is reshaping our understanding of fluid homeostasis and cellular waste management in the brain, but visualization and experimental analysis of these vessels is challenging in mammals. Although the optical clarity and experimental advantages of zebrafish have made this an essential model organism for studying lymphatic development, the existence of meningeal lymphatics has not yet been reported in this species.
objectiveExamine the intracranial space of larval, juvenile, and adult zebrafish to determine whether and where intracranial lymphatic vessels are present. METHODS AND
resultsUsing high-resolution optical imaging of the meninges in living animals, we show that zebrafish possess a meningeal lymphatic network comparable to that found in mammals. We confirm that this network is separate from the blood vascular network and that it drains interstitial fluid from the brain. We document the developmental origins and growth of these vessels into a distinct network separated from the external lymphatics. Finally, we show that these vessels contain immune cells and perform live imaging of immune cell trafficking and transmigration in meningeal lymphatics.
conclusionsThis discovery establishes the zebrafish as a important new model for experimental analysis of meningeal lymphatic development and opens up new avenues for probing meningeal lymphatic function in health and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.